E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

Naveen Pokala, Naveen Alasyam, Kavitha Rasamal.

Cited by (1)

Abstract
Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several diseases. As the treatment of fever was one such remedy, we found that not much work has been done on the antipyretic effect of these plants.

Aims and Objective: The aims and objective of this study were to evaluate and compare the antipyretic activity of aqueous leaf extracts of V. negundo and A. paniculata in rabbits.

Materials and Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 1000–1500 g were used in the study. The animals were divided into five groups (n = 6) in both the sets. The rabbits of all the groups were made febrile by administrating misoprostol (prostaglandin E1) subcutaneously in the dose of 100 mcg/kg. For Groups 1 and 2, normal saline 2 ml/kg as control and aspirin 28 mg/kg as standard were given, respectively, in both the sets. V. negundo and A. paniculata in the doses of 200, 400, and 800 mg/kg were given in remaining three groups of both sets, respectively. Rectal temperatures were monitored for every 30 min after treatment started up to 240 min, and its effects were compared to aspirin.

Results: Aqueous extracts of V. negundo and A. paniculata produced highly significant (P < 0.001) antipyretic effect in 400 and 800 mg/kg doses. However, the onset of action was fast with V. negundo.

Conclusion: The study concludes that aqueous extract of V. negundo has fast onset and sustained antipyretic action in New Zealand rabbits, whereas A. paniculata has delayed onset and sustained antipyretic effect.

Key words: Andrographis paniculata; Antipyretic; Digital Thermometer; Prostaglandin E1; Vitex negundo


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Naveen Pokala
Articles by Naveen Alasyam
Articles by Kavitha Rasamal
on Google
on Google Scholar
Article Statistics
 Viewed: 1474
Downloaded: 157
Cited: 1


This Article Cited By the following articles

Andrographolide, A Natural Antioxidant: An Update
Antioxidants 2019; 8(12): 571.

1
 
How to Cite this Article
Pubmed Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 556-561. doi:10.5455/njppp.2019.9.0412713042019


Web Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. http://www.njppp.com/?mno=41407 [Access: February 15, 2020]. doi:10.5455/njppp.2019.9.0412713042019


AMA (American Medical Association) Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 556-561. doi:10.5455/njppp.2019.9.0412713042019



Vancouver/ICMJE Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. (2019), [cited February 15, 2020]; 9(6): 556-561. doi:10.5455/njppp.2019.9.0412713042019



Harvard Style

Pokala, N., Alasyam, . N. & Rasamal, . K. (2019) Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol, 9 (6), 556-561. doi:10.5455/njppp.2019.9.0412713042019



Turabian Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. 2019. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 556-561. doi:10.5455/njppp.2019.9.0412713042019



Chicago Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. "Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 556-561. doi:10.5455/njppp.2019.9.0412713042019



MLA (The Modern Language Association) Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. "Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits." National Journal of Physiology, Pharmacy and Pharmacology 9.6 (2019), 556-561. Print. doi:10.5455/njppp.2019.9.0412713042019



APA (American Psychological Association) Style

Pokala, N., Alasyam, . N. & Rasamal, . K. (2019) Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 556-561. doi:10.5455/njppp.2019.9.0412713042019





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Most Cited Articles
  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 11 times [Click to see citing articles]

  • Pattern of mobile phone usage and its effects on psychological health, sleep, and academic performance in students of a medical university
    Naveenta Gupta, Sonia Garg, Khushdeep Arora
    Natl J Physiol Pharm Pharmacol. 2016; 6(2): 132-139
    » Abstract & References » doi: 10.5455/njppp.2016.6.0311201599
    Cited : 11 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 11 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 10 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 7 times [Click to see citing articles]