E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

Naveen Pokala, Naveen Alasyam, Kavitha Rasamal.

Abstract
Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several diseases. As the treatment of fever was one such remedy, we found that not much work has been done on the antipyretic effect of these plants.

Aims and Objective: The aims and objective of this study were to evaluate and compare the antipyretic activity of aqueous leaf extracts of V. negundo and A. paniculata in rabbits.

Materials and Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 1000–1500 g were used in the study. The animals were divided into five groups (n = 6) in both the sets. The rabbits of all the groups were made febrile by administrating misoprostol (prostaglandin E1) subcutaneously in the dose of 100 mcg/kg. For Groups 1 and 2, normal saline 2 ml/kg as control and aspirin 28 mg/kg as standard were given, respectively, in both the sets. V. negundo and A. paniculata in the doses of 200, 400, and 800 mg/kg were given in remaining three groups of both sets, respectively. Rectal temperatures were monitored for every 30 min after treatment started up to 240 min, and its effects were compared to aspirin.

Results: Aqueous extracts of V. negundo and A. paniculata produced highly significant (P < 0.001) antipyretic effect in 400 and 800 mg/kg doses. However, the onset of action was fast with V. negundo.

Conclusion: The study concludes that aqueous extract of V. negundo has fast onset and sustained antipyretic action in New Zealand rabbits, whereas A. paniculata has delayed onset and sustained antipyretic effect.

Key words: Andrographis paniculata; Antipyretic; Digital Thermometer; Prostaglandin E1; Vitex negundo


 
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How to Cite this Article
Pubmed Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 556-561. doi:10.5455/njppp.2019.9.0412713042019


Web Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. http://www.njppp.com/?mno=41407 [Access: August 23, 2019]. doi:10.5455/njppp.2019.9.0412713042019


AMA (American Medical Association) Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 556-561. doi:10.5455/njppp.2019.9.0412713042019



Vancouver/ICMJE Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. (2019), [cited August 23, 2019]; 9(6): 556-561. doi:10.5455/njppp.2019.9.0412713042019



Harvard Style

Pokala, N., Alasyam, . N. & Rasamal, . K. (2019) Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol, 9 (6), 556-561. doi:10.5455/njppp.2019.9.0412713042019



Turabian Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. 2019. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 556-561. doi:10.5455/njppp.2019.9.0412713042019



Chicago Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. "Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 556-561. doi:10.5455/njppp.2019.9.0412713042019



MLA (The Modern Language Association) Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. "Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits." National Journal of Physiology, Pharmacy and Pharmacology 9.6 (2019), 556-561. Print. doi:10.5455/njppp.2019.9.0412713042019



APA (American Psychological Association) Style

Pokala, N., Alasyam, . N. & Rasamal, . K. (2019) Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 556-561. doi:10.5455/njppp.2019.9.0412713042019





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