E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Nerve conduction study of median nerve with severity of airway obstruction

Sanjeev Kumar Shrivastava, Rashmi Dave, Asha Shrivastava.

Abstract
Background: Chronic obstructive pulmonary disease (COPD) is frequently associated with significant extrapulmonary manifestations. Hypoxemia resulting in peripheral neuropathy is known to occur as a systemic manifestation of COPD.

Aims and Objectives: This study aims to analyze the abnormalities of sensory and motor component of median nerve in stable COPD patients and correlate the changes with severity of COPD, duration of disease, and pack-years.

Materials and Methods: The study comprised 60 stable COPD patients (40–50 years) with no clinical neuropathy. Duration of illness, pack-years, and spirometric indices (forced expiratory volume in 1 s % [FEV1%], FEV1/forced vital capacity, and peak expiratory flow rate %) were assessed. Electrodiagnostic study of the right and left median nerve was done using root mean square EMG MKII. Distal latency, nerve conduction velocity, and action potential (compound motor action potential [CMAP] and sensory nerve action potential [SNAP]) for median motor and sensory nerve were analyzed. COPD patients were classified on the basis of the level of airway obstruction (FEV1 >50% and FEV1< 50%) into two groups and correlation of electrodiagnostic variables of these two groups with duration of illness, pack-years, and level of airway obstruction was established.

Results: CMAP of the left median motor nerve was reduced with increasing severity of disease. Significant correlation was established with spirometric variables, quantum of smoking, and duration of illness.

Conclusion: Airway obstruction leads to changes in arterial blood gas analysis (hypoxemia, hypercapnia, and acidosis) resulting in impairment of nerve conduction.

Key words: Chronic Obstructive Pulmonary Disease; Hypoxemia; Demyelination


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sanjeev Kumar Shrivastava
Articles by Rashmi Dave
Articles by Asha Shrivastava
on Google
on Google Scholar
Article Statistics
 Viewed: 1482
Downloaded: 115


How to Cite this Article
Pubmed Style

Shrivastava SK, Dave R, Shrivastava A. Nerve conduction study of median nerve with severity of airway obstruction. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 534-539. doi:10.5455/njppp.2019.9.0311328032019


Web Style

Shrivastava SK, Dave R, Shrivastava A. Nerve conduction study of median nerve with severity of airway obstruction. http://www.njppp.com/?mno=39321 [Access: February 15, 2020]. doi:10.5455/njppp.2019.9.0311328032019


AMA (American Medical Association) Style

Shrivastava SK, Dave R, Shrivastava A. Nerve conduction study of median nerve with severity of airway obstruction. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 534-539. doi:10.5455/njppp.2019.9.0311328032019



Vancouver/ICMJE Style

Shrivastava SK, Dave R, Shrivastava A. Nerve conduction study of median nerve with severity of airway obstruction. Natl J Physiol Pharm Pharmacol. (2019), [cited February 15, 2020]; 9(6): 534-539. doi:10.5455/njppp.2019.9.0311328032019



Harvard Style

Shrivastava, S. K., Dave, . R. & Shrivastava, . A. (2019) Nerve conduction study of median nerve with severity of airway obstruction. Natl J Physiol Pharm Pharmacol, 9 (6), 534-539. doi:10.5455/njppp.2019.9.0311328032019



Turabian Style

Shrivastava, Sanjeev Kumar, Rashmi Dave, and Asha Shrivastava. 2019. Nerve conduction study of median nerve with severity of airway obstruction. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 534-539. doi:10.5455/njppp.2019.9.0311328032019



Chicago Style

Shrivastava, Sanjeev Kumar, Rashmi Dave, and Asha Shrivastava. "Nerve conduction study of median nerve with severity of airway obstruction." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 534-539. doi:10.5455/njppp.2019.9.0311328032019



MLA (The Modern Language Association) Style

Shrivastava, Sanjeev Kumar, Rashmi Dave, and Asha Shrivastava. "Nerve conduction study of median nerve with severity of airway obstruction." National Journal of Physiology, Pharmacy and Pharmacology 9.6 (2019), 534-539. Print. doi:10.5455/njppp.2019.9.0311328032019



APA (American Psychological Association) Style

Shrivastava, S. K., Dave, . R. & Shrivastava, . A. (2019) Nerve conduction study of median nerve with severity of airway obstruction. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 534-539. doi:10.5455/njppp.2019.9.0311328032019





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Most Cited Articles
  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 11 times [Click to see citing articles]

  • Pattern of mobile phone usage and its effects on psychological health, sleep, and academic performance in students of a medical university
    Naveenta Gupta, Sonia Garg, Khushdeep Arora
    Natl J Physiol Pharm Pharmacol. 2016; 6(2): 132-139
    » Abstract & References » doi: 10.5455/njppp.2016.6.0311201599
    Cited : 11 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 11 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 10 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 7 times [Click to see citing articles]