E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Dose comparative evaluation of analgesic activity of simvastatin in wistar rats

Krishnagouda Patil, Suneel Kumar Reddy.

Abstract
Background: Pain is defined as an unpleasant sensation and emotional experience associated with or without tissue damage. Analgesics are the drugs that relieve pain. Statins are mainly employed in the treatment of hyperlipidaemias. Simvastatin belongs to HMG-CoA reductase inhibitors, which is the rate limiting step in the cholesterol synthesis. Analgesic effect of Simvastatin is a pleotropic effect, but the exact mechanism is not known. During our literature search we came across limited number of studies that evaluated the analgesic activity of simvastatin at different doses; however, the results were controversial at lower doses. Hence this study was under taken to evaluate analgesic activity Simvastatin at different doses in Wistar rats and also to compare its analgesic activity with Tramadol.

Aims and Objectives: (i) To evaluate analgesic activity Simvastatin at different doses in Wistar rats; (ii) To compare the analgesic activity of Simvastatin with Tramadol.

Materials and Methods: Analgesic activity of simvastatin was evaluated wistar rats using Tail Flick Model and Eddy’s Hot Plate Model. Normal saline with Polyethylene glycol (2 ml/kg), Tramadol (10 mg/kg), Simvastatin (5 mg/kg, 10 mg/kg and 30 mg/kg) dissolved in Polyethylene glycol, were given orally to the randomly divided 5 groups of 6 animals each. Maximum possible analgesia was calculated at 30, 60 and 90 min in both the models and compared between the 5 groups. Observations were analysed using ANOVA and post hoc Tukey’s test.

Results: Simvastatin at doses 5 mg/kg and 10 mg/kg body weight produced significant Maximal possible analgesia at 30 and 60 min in both the models (<0.001). Whereas dose of simvastatin i.e 30 mg/kg body weight produced significant Maximal possible analgesia at 30, 60 and 90 min in both models. (<0.001). These results were comparable to tramadol in both the models.

Conclusions: Simvastatin showed analgesic activity in both Tail Flick model and Eddy’s Hot Plate.

Key words: Analgesic Activity; Simvastatin; Tramadol; Tail Flick Model; Eddy’s Hot Plate


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Krishnagouda Patil
Articles by Suneel Kumar Reddy
on Google
on Google Scholar
Article Statistics
 Viewed: 777
Downloaded: 109
Cited: 0


How to Cite this Article
Pubmed Style

Patil K, Reddy SK. Dose comparative evaluation of analgesic activity of simvastatin in wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 472-475. doi:10.5455/njppp.2019.9.0204314032019


Web Style

Patil K, Reddy SK. Dose comparative evaluation of analgesic activity of simvastatin in wistar rats. http://www.njppp.com/?mno=30353 [Access: June 16, 2019]. doi:10.5455/njppp.2019.9.0204314032019


AMA (American Medical Association) Style

Patil K, Reddy SK. Dose comparative evaluation of analgesic activity of simvastatin in wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 472-475. doi:10.5455/njppp.2019.9.0204314032019



Vancouver/ICMJE Style

Patil K, Reddy SK. Dose comparative evaluation of analgesic activity of simvastatin in wistar rats. Natl J Physiol Pharm Pharmacol. (2019), [cited June 16, 2019]; 9(6): 472-475. doi:10.5455/njppp.2019.9.0204314032019



Harvard Style

Patil, K. & Reddy, . S. K. (2019) Dose comparative evaluation of analgesic activity of simvastatin in wistar rats. Natl J Physiol Pharm Pharmacol, 9 (6), 472-475. doi:10.5455/njppp.2019.9.0204314032019



Turabian Style

Patil, Krishnagouda, and Suneel Kumar Reddy. 2019. Dose comparative evaluation of analgesic activity of simvastatin in wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 472-475. doi:10.5455/njppp.2019.9.0204314032019



Chicago Style

Patil, Krishnagouda, and Suneel Kumar Reddy. "Dose comparative evaluation of analgesic activity of simvastatin in wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 472-475. doi:10.5455/njppp.2019.9.0204314032019



MLA (The Modern Language Association) Style

Patil, Krishnagouda, and Suneel Kumar Reddy. "Dose comparative evaluation of analgesic activity of simvastatin in wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 9.6 (2019), 472-475. Print. doi:10.5455/njppp.2019.9.0204314032019



APA (American Psychological Association) Style

Patil, K. & Reddy, . S. K. (2019) Dose comparative evaluation of analgesic activity of simvastatin in wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 472-475. doi:10.5455/njppp.2019.9.0204314032019





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Comparison of bleeding time and clotting time between males and females
    Ritu Adhana, Rajanish Chaurasiya, Anjali Verma
    Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1388-1390
    » Abstract » doi: 10.5455/ijmsph.2018.06201417062018

  • Effectiveness of “case-based learning” in physiology
    Amruta S Bennal, Manohar Y Pattar, Raju H Taklikar
    Natl J Physiol Pharm Pharmacol. 2016; 6(1): 65-67
    » Abstract & References » doi: 10.5455/njppp.2015.5.1810201583

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Most Cited Articles
  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 10 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 9 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 6 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 5 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 5 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 5 times [Click to see citing articles]

  • Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation
    Rasha R Ahmed, Ayman M Mahmoud, Mohamed B Ashour, Amira M Kamel
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 391-397
    » Abstract & References » doi: 10.5455/njppp.2015.5.2907201567
    Cited : 5 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]