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Original Research 


Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol

Omar M Ali, Hamada H Amer, Eman-Abdeen, Omima H Khallaf.

Abstract
Background: α-Aminophosphonate derivatives have an important biological activity against bacteria, fungi, and anticancer activity.

Aims and Objectives: This study aims to study preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol.

Materials and Methods: A series of α-aminophosphonate analogs and arylidene derivatives were synthesized, monitored by thin-layer chromatography, purified by chromatographic methods, and the structures were elucidated by spectroscopic methods such as H nuclear magnetic resonance. The synthesized compounds were tested for their antibacterial activity by hole well method against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive), the antibacterial activity was evaluated based on inhibition zone size around dishes against Gram-positive.

Results: Compounds 7e, 8a, 7c, 8b, and 8g are showed different degree of inhibitory effect against S. aureus; on the other hand in Gram-negative, the compounds 7a, 7c, 7d, 7e, 8a, 8b, and 8g are showed different degree of inhibitory effect against E. coli. In this study, we concluded that the results showed that increasing the zone inhibition in compared with amoxicillin and tetracycline against E. coli and S. aureus. Most of the compounds tested against microbes showed a moderate to high effect while few compounds showed a low antimicrobial effect.

Conclusion: In this study, we recommended that α-aminophosphonate and arylidene derivatives used as antimicrobial agents.

Key words: Arylidene Derivatives; α-Aminophosphonates; Antimicrobial activity


 
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Pubmed Style

Ali OM, Amer HH, , Khallaf OH. Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol. Natl J Physiol Pharm Pharmacol. 2018; 8(8): 1219-1225. doi:10.5455/njppp.2018.8.0517614052018


Web Style

Ali OM, Amer HH, , Khallaf OH. Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol. http://www.njppp.com/?mno=298262 [Access: August 21, 2018]. doi:10.5455/njppp.2018.8.0517614052018


AMA (American Medical Association) Style

Ali OM, Amer HH, , Khallaf OH. Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol. Natl J Physiol Pharm Pharmacol. 2018; 8(8): 1219-1225. doi:10.5455/njppp.2018.8.0517614052018



Vancouver/ICMJE Style

Ali OM, Amer HH, , Khallaf OH. Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol. Natl J Physiol Pharm Pharmacol. (2018), [cited August 21, 2018]; 8(8): 1219-1225. doi:10.5455/njppp.2018.8.0517614052018



Harvard Style

Ali, O. M., Amer, H. H., & Khallaf, O. H. (2018) Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol. Natl J Physiol Pharm Pharmacol, 8 (8), 1219-1225. doi:10.5455/njppp.2018.8.0517614052018



Turabian Style

Ali, Omar M, Hamada H Amer, Eman-Abdeen, and Omima H Khallaf. 2018. Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol. National Journal of Physiology, Pharmacy and Pharmacology, 8 (8), 1219-1225. doi:10.5455/njppp.2018.8.0517614052018



Chicago Style

Ali, Omar M, Hamada H Amer, Eman-Abdeen, and Omima H Khallaf. "Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1219-1225. doi:10.5455/njppp.2018.8.0517614052018



MLA (The Modern Language Association) Style

Ali, Omar M, Hamada H Amer, Eman-Abdeen, and Omima H Khallaf. "Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol." National Journal of Physiology, Pharmacy and Pharmacology 8.8 (2018), 1219-1225. Print. doi:10.5455/njppp.2018.8.0517614052018



APA (American Psychological Association) Style

Ali, O. M., Amer, H. H., & Khallaf, O. H. (2018) Preparation, spectroscopic, and biological characterizations of novel α-aminophosphonates bearing paracetamol. National Journal of Physiology, Pharmacy and Pharmacology, 8 (8), 1219-1225. doi:10.5455/njppp.2018.8.0517614052018





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