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Original Research Open Access


Leptin signaling - Leptin resistance in obesity and its correlation with body mass index

Vanita Sharma, Neena Sharma.

Abstract
Background: Obesity is a worldwide problem and is a risk factor for multiple health problems. Leptin is an adipokine with a role in energy homeostasis and interruption in its action leads to obesity.

Aims and Objectives: The present study is conducted to determine leptin levels in obese and normal weight adults and correlate the leptin levels with body mass index (BMI) among obese.

Materials and Methods: The study comprised of 50 healthy obese subjects and 20 normal weight controls in the age group of 3045 years of either sex. BMI and serum leptin were measured for both subjects and control.

Results: The study demonstrates higher leptin levels in obese as compared to normal weight adults (P < 0.0001) and significant positive Pearson correlation coefficient between serum leptin and BMI among obese.

Conclusion: Leptin circulates excessively in obese, and measures should be taken to reduce the refractoriness of leptin to regulate the energy homeostasis.

Key words: Leptin; Obesity; Body Mass Index


 
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How to Cite this Article
Pubmed Style

Sharma V, Sharma N. Leptin signaling - Leptin resistance in obesity and its correlation with body mass index. doi:10.5455/njppp.2018.8.0102230012018


Web Style

Sharma V, Sharma N. Leptin signaling - Leptin resistance in obesity and its correlation with body mass index. http://www.njppp.com/?mno=288481 [Access: February 23, 2018]. doi:10.5455/njppp.2018.8.0102230012018


AMA (American Medical Association) Style

Sharma V, Sharma N. Leptin signaling - Leptin resistance in obesity and its correlation with body mass index. doi:10.5455/njppp.2018.8.0102230012018



Vancouver/ICMJE Style

Sharma V, Sharma N. Leptin signaling - Leptin resistance in obesity and its correlation with body mass index. doi:10.5455/njppp.2018.8.0102230012018



Harvard Style

Sharma, V. & Sharma, N. (2018) Leptin signaling - Leptin resistance in obesity and its correlation with body mass index. doi:10.5455/njppp.2018.8.0102230012018



Turabian Style

Sharma, Vanita, and Neena Sharma. 2018. Leptin signaling - Leptin resistance in obesity and its correlation with body mass index. doi:10.5455/njppp.2018.8.0102230012018



Chicago Style

Sharma, Vanita, and Neena Sharma. "Leptin signaling - Leptin resistance in obesity and its correlation with body mass index." doi:10.5455/njppp.2018.8.0102230012018



MLA (The Modern Language Association) Style

Sharma, Vanita, and Neena Sharma. "Leptin signaling - Leptin resistance in obesity and its correlation with body mass index." doi:10.5455/njppp.2018.8.0102230012018



APA (American Psychological Association) Style

Sharma, V. & Sharma, N. (2018) Leptin signaling - Leptin resistance in obesity and its correlation with body mass index. doi:10.5455/njppp.2018.8.0102230012018



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