E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study

Mahesh N Belhekar, Kiran A Bhave, Tejal C Patel, Prasad R Pandit, Saurabh L Mandaknalli, Krishna V Mundada.

Abstract
Background: Inappropriate and indiscriminate use of fixed-dose drug combinations (FDCs) may lead to increased cost, unnecessary exposure to drugs, and adverse drug reactions. Government of India had issued a ban notification on manufacturing and sale of few FDCs which involved human risk and no therapeutic justification for their use. Despite the stringent steps from the health-care authorities, such FDCs are available in the market and are being prescribed extensively without considering the appropriate alternative in the form of a single drug formulation.

Aims and Objective: This study was planned to find out the number FDCs prescribed by clinicians and find out the rationality with respect to the indication.

Materials and Methods: Prescriptions of patients attending hospital pharmacy and indoor papers of patients admitted in the wards were screened for the presence of FDCs for a period of 6 months. A total of 3500 prescriptions were screened, and collected data were analyzed using descriptive statistics.

Results: Out of 3500 prescriptions screened, 1000 (28.5%) had FDCs prescribed in it. Out of 1000 FDCs, 151 (15.1%) were prescribed by generic names and 849 (84.9%) were prescribed by brand names. A total of 596 (59.6%) FDCs were prescribed for infectious diseases followed by 195 (19.5%) FDCs prescribed for pain and inflammatory disorders and 169 (16.9%) FDCs were prescribed for diseases affecting the respiratory system. Out of 1000 FDCs, 818 (81.8%) were rational and 182 (18.2%) were irrational.

Conclusion: The study revealed that the majority of prescriptions had rational FDCs prescribed by the treating doctors reflecting rational use of
FDCs in our patients.

Key words: Fixed-dose Combinations; Irrational; Prescription Patterns; Rational Use


 
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Pubmed Style

Belhekar MN, Bhave KA, Patel TC, Pandit PR, Mandaknalli SL, Mundada KV. Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2019; 9(5): 392-397. doi:10.5455/njppp.2019.9.01031105032019


Web Style

Belhekar MN, Bhave KA, Patel TC, Pandit PR, Mandaknalli SL, Mundada KV. Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study. http://www.njppp.com/?mno=28844 [Access: May 27, 2019]. doi:10.5455/njppp.2019.9.01031105032019


AMA (American Medical Association) Style

Belhekar MN, Bhave KA, Patel TC, Pandit PR, Mandaknalli SL, Mundada KV. Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2019; 9(5): 392-397. doi:10.5455/njppp.2019.9.01031105032019



Vancouver/ICMJE Style

Belhekar MN, Bhave KA, Patel TC, Pandit PR, Mandaknalli SL, Mundada KV. Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study. Natl J Physiol Pharm Pharmacol. (2019), [cited May 27, 2019]; 9(5): 392-397. doi:10.5455/njppp.2019.9.01031105032019



Harvard Style

Belhekar, M. N., Bhave, . K. A., Patel, . T. C., Pandit, . P. R., Mandaknalli, . S. L. & Mundada, . K. V. (2019) Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study. Natl J Physiol Pharm Pharmacol, 9 (5), 392-397. doi:10.5455/njppp.2019.9.01031105032019



Turabian Style

Belhekar, Mahesh N, Kiran A Bhave, Tejal C Patel, Prasad R Pandit, Saurabh L Mandaknalli, and Krishna V Mundada. 2019. Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 9 (5), 392-397. doi:10.5455/njppp.2019.9.01031105032019



Chicago Style

Belhekar, Mahesh N, Kiran A Bhave, Tejal C Patel, Prasad R Pandit, Saurabh L Mandaknalli, and Krishna V Mundada. "Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 392-397. doi:10.5455/njppp.2019.9.01031105032019



MLA (The Modern Language Association) Style

Belhekar, Mahesh N, Kiran A Bhave, Tejal C Patel, Prasad R Pandit, Saurabh L Mandaknalli, and Krishna V Mundada. "Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 9.5 (2019), 392-397. Print. doi:10.5455/njppp.2019.9.01031105032019



APA (American Psychological Association) Style

Belhekar, M. N., Bhave, . K. A., Patel, . T. C., Pandit, . P. R., Mandaknalli, . S. L. & Mundada, . K. V. (2019) Evaluation of prescription pattern of fixed-dose combinations in a tertiary care hospital in India – A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 9 (5), 392-397. doi:10.5455/njppp.2019.9.01031105032019





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