Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Original Research Open Access


Evaluation of analgesic activity of pioglitazone in albino mice

Shruthi S L, Kalabharathi H L, Dharani Devangi R.

Abstract
Background: Analgesics selectively relieve pain by acting either on central or peripheral pain pathways. Recently, studies have shown accumulating evidence to implicate N-methyl-d-aspartate receptors (NMDARs) mediation in central and peripheral sensitization and visceral pain leading to the possibility that NMDAR antagonists may be useful in the treatment of pain.

Aims and Objectives: (1) To evaluate analgesic activity of Pioglitazone (PIO) in mice. (2) To compare the analgesic activity of PIO with the standard drugs tramadol and aspirin, in mice.

Materials and Methods: Albino mice were divided into four groups, containing six animals (n = 6) in each group (control, standard, and test group). Group-I: Control received saline solution 2 ml/kg orally, Group-II: Standard 1 received tramadol at a dose of 10 mg/ kg intraperitoneal, Group-III: Standard 2 received aspirin at a dose of 300 mg/kg orally, and Group-IV: Test received PIO at a dose of 20 mg/kg orally. PIO and normal saline were administered 30 min before, whereas the tramadol and aspirin were administered 15 min before writhing and tail clip methods. The decrease in number of writhes and the delay in reaction time in tail clip method denoted the analgesic activity.

Results: PIO decreased the number of writhes and delayed the reaction time in tail clip method considerably when compared with control, but less when compared with standard drugs.

Conclusion: PIO exhibits analgesic activity in both chemical and mechanical pain models in albino mice.

Key words: Analgesic Activity; Pioglitazone; N-methyl-d-aspartate Receptor; Tail Flick Method; Acetic Acid-Induced Writhing Method


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Shruthi S L
Articles by Kalabharathi H L
Articles by Dharani Devangi R
on Google
on Google Scholar
Article Statistics
 Viewed: 70
Downloaded: 26
Cited: 0


How to Cite this Article
Pubmed Style

L SS, L KH, R DD. Evaluation of analgesic activity of pioglitazone in albino mice. doi:10.5455/njppp.2018.8.1144423112017


Web Style

L SS, L KH, R DD. Evaluation of analgesic activity of pioglitazone in albino mice. http://www.njppp.com/?mno=283624 [Access: January 24, 2018]. doi:10.5455/njppp.2018.8.1144423112017


AMA (American Medical Association) Style

L SS, L KH, R DD. Evaluation of analgesic activity of pioglitazone in albino mice. doi:10.5455/njppp.2018.8.1144423112017



Vancouver/ICMJE Style

L SS, L KH, R DD. Evaluation of analgesic activity of pioglitazone in albino mice. doi:10.5455/njppp.2018.8.1144423112017



Harvard Style

L, S. S., L, K. H. & R, D. D. (2018) Evaluation of analgesic activity of pioglitazone in albino mice. doi:10.5455/njppp.2018.8.1144423112017



Turabian Style

L, Shruthi S, Kalabharathi H L, and Dharani Devangi R. 2018. Evaluation of analgesic activity of pioglitazone in albino mice. doi:10.5455/njppp.2018.8.1144423112017



Chicago Style

L, Shruthi S, Kalabharathi H L, and Dharani Devangi R. "Evaluation of analgesic activity of pioglitazone in albino mice." doi:10.5455/njppp.2018.8.1144423112017



MLA (The Modern Language Association) Style

L, Shruthi S, Kalabharathi H L, and Dharani Devangi R. "Evaluation of analgesic activity of pioglitazone in albino mice." doi:10.5455/njppp.2018.8.1144423112017



APA (American Psychological Association) Style

L, S. S., L, K. H. & R, D. D. (2018) Evaluation of analgesic activity of pioglitazone in albino mice. doi:10.5455/njppp.2018.8.1144423112017



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Copernicus  (ICV 2016: 109)

Index Medicus for SEAR

CAB abstract/Global Health

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.