Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Original Research Open Access


Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats

Chandrashekar K, Rajashekar Y R, Ganesan R.

Abstract
Background: Dipeptidyl peptidase-4 enzyme not only inhibits incretins but also many other substrates and has wide distribution. Inhibition of this enzyme may have many implications, one of which is to improve wound healing.

Aims and Objectives: This aim of this study is to evaluate wound healing property of linagliptin, saxagliptin, sitagliptin, and vildagliptin on excised wounds in non-diabetic Wistar albino rats.

Materials and Methods: Some commonly used gliptins, linagliptin, saxagliptin, sitagliptin, and vildagliptin were assessed for pro-wound healing property on excised wound in non-diabetic Wistar albino rats. Wound healing was assessed by measuring the scar area at 4,8,12 & 16 days and the time taken for the complete scar formation.On the 16th day, rats were sacrificed, wound tissue biopsy was taken for assessing granulation tissue and serum was subjected for tumor necrosis factor-1α, interleukin-6, inducible nitric oxide synthase, hydroxyproline and glucose estimation.

Results: Pro-healing property was not uniform among various tested gliptins, only linagliptin and sitagliptin were found to have improved wound healing potential in rat excised wound.

Conclusion: Gliptins show variable effect on wound healing.

Key words: Dipeptidyl Peptidase-4 Enzyme; Pro-wound Healing Property


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Chandrashekar K
Articles by Rajashekar Y R
Articles by Ganesan R
on Google
on Google Scholar
Article Statistics
 Viewed: 148
Downloaded: 53
Cited: 0


How to Cite this Article
Pubmed Style

K C, R RY, R G. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1359-1363. doi:10.5455/njppp.2017.7.0832224082017


Web Style

K C, R RY, R G. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. http://www.njppp.com/?mno=275661 [Access: December 18, 2017]. doi:10.5455/njppp.2017.7.0832224082017


AMA (American Medical Association) Style

K C, R RY, R G. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Vancouver/ICMJE Style

K C, R RY, R G. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol. (2017), [cited December 18, 2017]; 7(12): 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Harvard Style

K, C., R, R. Y. & R, G. (2017) Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. Natl J Physiol Pharm Pharmacol, 7 (12), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Turabian Style

K, Chandrashekar, Rajashekar Y R, and Ganesan R. 2017. Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



Chicago Style

K, Chandrashekar, Rajashekar Y R, and Ganesan R. "Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



MLA (The Modern Language Association) Style

K, Chandrashekar, Rajashekar Y R, and Ganesan R. "Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 7.12 (2017), 1359-1363. Print. doi:10.5455/njppp.2017.7.0832224082017



APA (American Psychological Association) Style

K, C., R, R. Y. & R, G. (2017) Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1359-1363. doi:10.5455/njppp.2017.7.0832224082017



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Copernicus  (ICV 2016: 109)

Index Medicus for SEAR

CAB abstract/Global Health

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.