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Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models

Rajashekar Y R, Padmanabha T S, Chandrakantha T.

Abstract
Background: Diabetes mellitus is not only a chronic metabolic disorder but also an inflammatory one. Antidiabetic drugs are required to address both these entities to reduce the micro- and macro-complications associated with diabetes. Some of the incretin-based drugs have been shown to have decreased inflammatory markers. The studies on inflammatory models are very less.

Aims and Objectives: The aim of this study is to evaluate anti-inflammatory activities of liraglutide, a glucagon-like peptide-1 analog, and teneligliptin, a dipeptidyl peptidase-4 inhibitor in experimental acute and subacute models of inflammation and also to evaluate their interactions with ibuprofen, a standard non-steroidal anti-inflammatory drugs.

Materials and Methods: Carrageenan-induced paw edema to assess edema in acute anti-inflammatory action and cotton pellet-induced granuloma method to assess granuloma dry weight of liraglutide and teneligliptin in rats.

Results: Liraglutide did not show anti-edema and anti-granuloma activity but potentiated the anti-granuloma effect of ibuprofen. Teneligliptin showed only anti-granuloma effect and potentiated both anti-edema and anti-granuloma activities of ibuprofen.

Conclusion: Liraglutide and teneligliptin individually have variable anti-inflammatory activities, and they also have variable ibuprofen potentiating action. They have potentiated the subacute anti-inflammatory of ibuprofen by their anti-granuloma effect.

Key words: Liraglutide; Teneligliptin; Anti-inflammatory Action; Drug Potentiation


 
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How to Cite this Article
Pubmed Style

R RY, S PT, T C. Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 51-55. doi:10.5455/njppp.2018.8.0728808082017


Web Style

R RY, S PT, T C. Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models. http://www.njppp.com/?mno=273783 [Access: January 23, 2018]. doi:10.5455/njppp.2018.8.0728808082017


AMA (American Medical Association) Style

R RY, S PT, T C. Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 51-55. doi:10.5455/njppp.2018.8.0728808082017



Vancouver/ICMJE Style

R RY, S PT, T C. Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models. Natl J Physiol Pharm Pharmacol. (2018), [cited January 23, 2018]; 8(1): 51-55. doi:10.5455/njppp.2018.8.0728808082017



Harvard Style

R, R. Y., S, P. T. & T, C. (2018) Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models. Natl J Physiol Pharm Pharmacol, 8 (1), 51-55. doi:10.5455/njppp.2018.8.0728808082017



Turabian Style

R, Rajashekar Y, Padmanabha T S, and Chandrakantha T. 2018. Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 51-55. doi:10.5455/njppp.2018.8.0728808082017



Chicago Style

R, Rajashekar Y, Padmanabha T S, and Chandrakantha T. "Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 51-55. doi:10.5455/njppp.2018.8.0728808082017



MLA (The Modern Language Association) Style

R, Rajashekar Y, Padmanabha T S, and Chandrakantha T. "Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models." National Journal of Physiology, Pharmacy and Pharmacology 8.1 (2018), 51-55. Print. doi:10.5455/njppp.2018.8.0728808082017



APA (American Psychological Association) Style

R, R. Y., S, P. T. & T, C. (2018) Variable anti-edema and anti-granuloma effects of liraglutide and teneligliptin on experimental Wistar albino rat inflammatory models. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 51-55. doi:10.5455/njppp.2018.8.0728808082017



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