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Case Report Open Access


Arsenic trioxide-induced QT interval prolongation: A case report

Devika Mohan, Raghuveer Prabhu, Remya Reghu.

Abstract
QT prolongation refers to the prolonged QT interval in electrocardiography (ECG) which can even lead to life-threatening events such as ventricular arrhythmias, torsades de pointes, etc., several drugs can cause QT prolongation which includes sotalol, quinidine, arsenic, disopyramide, procainamide, amiodarone, haloperidol, etc., Arsenic trioxide (ATO) is used as an effective treatment option in promyelocytic leukemia (PML). Acute myeloid leukemia (AML) is a cancer that affects the blood and bone marrow. Acute promyelocytic leukemia (APL) is the M3 subtype of AML that affects mainly the white blood cells. In APL, immature granulocytes accumulate abnormally to form promyelocytes. ATO helps in the apoptosis of these cancerous promyelocytic cells. In patients on arsenic therapy, ECGs must be monitored to ensure QT prolongation as it a major side effect of the drug. Here is the case of a 58-year-old female patient and was newly diagnosed with APL. She developed QT prolongation with arsenic therapy. Other confounding factors such as electrolytes and presence of other QT-prolonging drugs were also corrected.

Key words: Acute Promyelocytic Leukemia; Promyelocytes; QT Prolongation; Torsades De Pointes; Arsenic Trioxide


 
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How to Cite this Article
Pubmed Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 878-880. doi:10.5455/njppp.2017.7.0621330062017



Web Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. www.scopemed.org/?mno=270206 [Access: August 16, 2017]. doi:10.5455/njppp.2017.7.0621330062017



AMA (American Medical Association) Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 878-880. doi:10.5455/njppp.2017.7.0621330062017



Vancouver/ICMJE Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol. (2017), [cited August 16, 2017]; 7(8): 878-880. doi:10.5455/njppp.2017.7.0621330062017



Harvard Style

Mohan, D., Prabhu, R. & Reghu, R. (2017) Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol, 7 (8), 878-880. doi:10.5455/njppp.2017.7.0621330062017



Turabian Style

Mohan, Devika, Raghuveer Prabhu, and Remya Reghu. 2017. Arsenic trioxide-induced QT interval prolongation: A case report. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 878-880. doi:10.5455/njppp.2017.7.0621330062017



Chicago Style

Mohan, Devika, Raghuveer Prabhu, and Remya Reghu. "Arsenic trioxide-induced QT interval prolongation: A case report." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 878-880. doi:10.5455/njppp.2017.7.0621330062017



MLA (The Modern Language Association) Style

Mohan, Devika, Raghuveer Prabhu, and Remya Reghu. "Arsenic trioxide-induced QT interval prolongation: A case report." National Journal of Physiology, Pharmacy and Pharmacology 7.8 (2017), 878-880. Print. doi:10.5455/njppp.2017.7.0621330062017



APA (American Psychological Association) Style

Mohan, D., Prabhu, R. & Reghu, R. (2017) Arsenic trioxide-induced QT interval prolongation: A case report. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 878-880. doi:10.5455/njppp.2017.7.0621330062017



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