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Original Research Open Access


Liver enzymes in obstructive sleep apnoea syndrome

Kanimozhi Sadasivam, Kuldeep Patial, Krishnan Ravi, Saravanan Aiyyavo.

Abstract
Background: Obstructive sleep apnea syndrome (OSAS) is a common form of sleep disordered breathing. OSAS is associated with the cluster of metabolic abbreations that comprise the metabolic syndrome, including nonalcoholic fatty liver disease.

Aims and Objectives: We investigated the effects of OSAS and its treatment with short term nasal continuous positive airway pressure (CPAP) therapy on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.

Materials and Methods: We studied 20 adult males and postmenopausal female aged 50-60 years with OSAS. None had hepatitis B antigen or C antibody positive, autoimmune disease, an alcohol intake higher than 20 g/day or on regular use of hepatotoxic drugs. Abdominal ultrasound was done to establish the presence of fatty liver. Serum levels of AST and ALT were determined at baseline and after nasal CPAP treatment.

Results: The baseline ALT and AST values were within normal limits. There was no significant change in ALT (25.9 ± 4.7 vs. 26.2 ± 3.4 after CPAP, P > 0.05) and AST (27.5 ± 2.0 vs. 24.6 ± 1.8, P > 0.05) values after one night of CPAP treatment.

Conclusion: Serum aminotransferase may have limited use in assessing liver damage in the OSAS patients. Short term CPAP therapy doesn’t seem have beneficial effects on serum aminotransferase levels in patients of OSAS.

Key words: Obstructive Sleep Apnea Syndrome; Continuous Positive Airway Pressure; Nonalcoholic Fatty Liver Disease; Serum Aminotransferease


 
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How to Cite this Article
Pubmed Style

Sadasivam K, Patial K, Ravi K, Aiyyavo S. Liver enzymes in obstructive sleep apnoea syndrome. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 865-869. doi:10.5455/njppp.2017.7.0414006052017



Web Style

Sadasivam K, Patial K, Ravi K, Aiyyavo S. Liver enzymes in obstructive sleep apnoea syndrome. www.scopemed.org/?mno=265268 [Access: August 16, 2017]. doi:10.5455/njppp.2017.7.0414006052017



AMA (American Medical Association) Style

Sadasivam K, Patial K, Ravi K, Aiyyavo S. Liver enzymes in obstructive sleep apnoea syndrome. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 865-869. doi:10.5455/njppp.2017.7.0414006052017



Vancouver/ICMJE Style

Sadasivam K, Patial K, Ravi K, Aiyyavo S. Liver enzymes in obstructive sleep apnoea syndrome. Natl J Physiol Pharm Pharmacol. (2017), [cited August 16, 2017]; 7(8): 865-869. doi:10.5455/njppp.2017.7.0414006052017



Harvard Style

Sadasivam, K., Patial, K., Ravi, K. & Aiyyavo, S. (2017) Liver enzymes in obstructive sleep apnoea syndrome. Natl J Physiol Pharm Pharmacol, 7 (8), 865-869. doi:10.5455/njppp.2017.7.0414006052017



Turabian Style

Sadasivam, Kanimozhi, Kuldeep Patial, Krishnan Ravi, and Saravanan Aiyyavo. 2017. Liver enzymes in obstructive sleep apnoea syndrome. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 865-869. doi:10.5455/njppp.2017.7.0414006052017



Chicago Style

Sadasivam, Kanimozhi, Kuldeep Patial, Krishnan Ravi, and Saravanan Aiyyavo. "Liver enzymes in obstructive sleep apnoea syndrome." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 865-869. doi:10.5455/njppp.2017.7.0414006052017



MLA (The Modern Language Association) Style

Sadasivam, Kanimozhi, Kuldeep Patial, Krishnan Ravi, and Saravanan Aiyyavo. "Liver enzymes in obstructive sleep apnoea syndrome." National Journal of Physiology, Pharmacy and Pharmacology 7.8 (2017), 865-869. Print. doi:10.5455/njppp.2017.7.0414006052017



APA (American Psychological Association) Style

Sadasivam, K., Patial, K., Ravi, K. & Aiyyavo, S. (2017) Liver enzymes in obstructive sleep apnoea syndrome. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 865-869. doi:10.5455/njppp.2017.7.0414006052017



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