Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Original Research Open Access


Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial

Shadab Munawar Moosa, Maaz Hussain Syed, Yaser Mohammed Askari.

Abstract
Background: Musculoskeletal diseases with painful reflex muscle spasm have a high prevalence. Because of reflex muscle spasm, muscle relaxants are frequently used either alone or in combination with analgesics. Eperisone inhibits voltage-gated sodium channels in brain stem and tizanidine acts on imidazoline and α2-adrenergic receptor to relax muscle spasm and relieves pain. The development of sedation seems to be the major limiting factor in the use of muscle relaxants for treatment as they can affect daily activity and decrease working capability.

Aims and Objectives: The present trial conducted to evaluate the effect of eperisone and tizanidine on visual and auditory reaction time.

Materials and Methods: This was a prospective, double-blind, parallel group, randomized clinical trial. A total of 115 patients were randomized into two groups. Patients in Group A received tablet eperisone 100 mg and patients in Group B received tablet tizanidine 2 mg for 7 days. Primary outcome measures were changed in visual and auditory reaction time from baseline to day 7. Secondary outcome measure of the trial was change in the visual analog scale (VAS) is the most common research tool used to measure pain. VAS score of the sedation from baseline to day 7.

Results: On day 7, the difference in visual reaction time in Group A and B was 0.014 and 0.077, respectively, and this difference is statistically significant (P = 0.029). Difference in Auditory reaction time on day 7 in Group A and B were 0.007 and 0.091, respectively, and it is statistically significant (P = 0.004). There was increase in sedation score in Group B by 0.34 and it is statistically significant (P = 0.015).

Conclusion: Tizanidine increases visual and auditory reaction time and sedation which is not seen with eperisone. Eperisone is a preferred alternative for muscle relaxation to avoid these effects.

Key words: Muscle Spasm; Eperisone; Tizanidine


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Shadab Munawar Moosa
Articles by Maaz Hussain Syed
Articles by Yaser Mohammed Askari
on Google
on Google Scholar
Article Statistics
 Viewed: 319
Downloaded: 67
Cited: 0


How to Cite this Article
Pubmed Style

Moosa SM, Syed MH, Askari YM. Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 839-843. doi:10.5455/njppp.2017.7.0309517042017



Web Style

Moosa SM, Syed MH, Askari YM. Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial. www.scopemed.org/?mno=262661 [Access: October 19, 2017]. doi:10.5455/njppp.2017.7.0309517042017



AMA (American Medical Association) Style

Moosa SM, Syed MH, Askari YM. Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 839-843. doi:10.5455/njppp.2017.7.0309517042017



Vancouver/ICMJE Style

Moosa SM, Syed MH, Askari YM. Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial. Natl J Physiol Pharm Pharmacol. (2017), [cited October 19, 2017]; 7(8): 839-843. doi:10.5455/njppp.2017.7.0309517042017



Harvard Style

Moosa, S. M., Syed, M. H. & Askari, Y. M. (2017) Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial. Natl J Physiol Pharm Pharmacol, 7 (8), 839-843. doi:10.5455/njppp.2017.7.0309517042017



Turabian Style

Moosa, Shadab Munawar, Maaz Hussain Syed, and Yaser Mohammed Askari. 2017. Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 839-843. doi:10.5455/njppp.2017.7.0309517042017



Chicago Style

Moosa, Shadab Munawar, Maaz Hussain Syed, and Yaser Mohammed Askari. "Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 839-843. doi:10.5455/njppp.2017.7.0309517042017



MLA (The Modern Language Association) Style

Moosa, Shadab Munawar, Maaz Hussain Syed, and Yaser Mohammed Askari. "Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial." National Journal of Physiology, Pharmacy and Pharmacology 7.8 (2017), 839-843. Print. doi:10.5455/njppp.2017.7.0309517042017



APA (American Psychological Association) Style

Moosa, S. M., Syed, M. H. & Askari, Y. M. (2017) Efficacy of eperisone and tizanidine on visual and auditory reaction time: A prospective, double-blind randomized controlled trial. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 839-843. doi:10.5455/njppp.2017.7.0309517042017



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Copernicus  (ICV 2015: 92.35)

Index Medicus for SEAR

CAB abstract/Global Health

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.