E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease

Shah Mohammad Abbas Waseem.

Abstract
Background: Oxidative stress, inflammation, and hypoxia, which are associated with chronic obstructive pulmonary disease (COPD) may contribute to auditory impairment.

Aims and Objectives: The present study was undertaken to assess the brainstem auditory evoked potential (BAEP) of smokers and non-smokers with or without COPD.

Materials and Methods: The study comprised smokers with (n = 25) or without COPD (n = 15) and also healthy non-smokers (n = 30). Oxidative stress was assessed by malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP). Pulmonary functions were determined. Data were analyzed using ANOVA and Pearsonís correlation tests. P < 0.05 was considered statistically significant.

Results: Spirometric values were significantly lower in COPD group in comparison with other two groups. Oxidant/antioxidant imbalance was more in smokers with COPD. BAEP result (both right and left ear) showed no significant difference between non-smokers and smokers without COPD in Wave I (P = 0.885 and 0.085, respectively) and in wave II (P = 0.554 and 0.396, respectively). Significant difference (both ears) was found between non-smokers and smokers with and without COPD in waves III, IV, V, and IPL I-V. MDA showed significant negative and positive correlations with FRAP, wave latencies, and IPL. Significant negative correlation was found between pack years and FRAP. However, non-significant positive correlation was found with MDA. Significant positive correlation was found between pack years and wave latencies III, IV, and V and interpeak latency I-V in both ears.

Conclusion: Smoking-induced oxidative stress as well as increased susceptibility to COPD, which in turn led to hypoxia and effects the auditory mechanisms and these are responsible for BAEP abnormalities.

Key words: Smokers; Non-smokers; Chronic Obstructive Pulmonary Disease; Pulmonary Functions; Brainstem Auditory Evoked Potential; Oxidant/Antioxidant


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Shah Mohammad Abbas Waseem
on Google
on Google Scholar
Article Statistics
 Viewed: 1034
Downloaded: 425
Cited: 0

How to Cite this Article
Pubmed Style

Shah Mohammad Abbas Waseem. Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. 2018; 8(2): 152-157. doi:10.5455/njppp.2018.8.0308617082017


Web Style

Shah Mohammad Abbas Waseem. Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease. http://www.njppp.com/?mno=262189 [Access: September 21, 2018]. doi:10.5455/njppp.2018.8.0308617082017


AMA (American Medical Association) Style

Shah Mohammad Abbas Waseem. Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. 2018; 8(2): 152-157. doi:10.5455/njppp.2018.8.0308617082017



Vancouver/ICMJE Style

Shah Mohammad Abbas Waseem. Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. (2018), [cited September 21, 2018]; 8(2): 152-157. doi:10.5455/njppp.2018.8.0308617082017



Harvard Style

Shah Mohammad Abbas Waseem (2018) Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol, 8 (2), 152-157. doi:10.5455/njppp.2018.8.0308617082017



Turabian Style

Shah Mohammad Abbas Waseem. 2018. Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease. National Journal of Physiology, Pharmacy and Pharmacology, 8 (2), 152-157. doi:10.5455/njppp.2018.8.0308617082017



Chicago Style

Shah Mohammad Abbas Waseem. "Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 152-157. doi:10.5455/njppp.2018.8.0308617082017



MLA (The Modern Language Association) Style

Shah Mohammad Abbas Waseem. "Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease." National Journal of Physiology, Pharmacy and Pharmacology 8.2 (2018), 152-157. Print. doi:10.5455/njppp.2018.8.0308617082017



APA (American Psychological Association) Style

Shah Mohammad Abbas Waseem (2018) Smoking-induced oxidant/antioxidant imbalance in chronic obstructive pulmonary disease: Assessment of auditory evoked potential: A comparative study of smokers and non-smokers with or without chronic obstructive pulmonary disease. National Journal of Physiology, Pharmacy and Pharmacology, 8 (2), 152-157. doi:10.5455/njppp.2018.8.0308617082017





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Most Cited Articles
  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 8 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimerís disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 6 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]

  • Effects of sixteen weeks exercise training on left ventricular dimensions and function in young athletes
    Sandip M Hulke, Yuganti P Vaidya, Amandeepkour R Ratta
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 152-158
    » Abstract & References » doi: 10.5455/njppp.2012.2.152-158
    Cited : 4 times [Click to see citing articles]

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138
    Cited : 4 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 4 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 4 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 4 times [Click to see citing articles]