Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris

Satish G R; Laxminarayana Kamath; Revathi T N

doi:10.5455/njppp.2017.7.0102027022017

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Online Publishing Date:
14 / 03 / 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(7): 674-678

doi: 10.5455/njppp.2017.7.0102027022017

Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris

Satish G R, Laxminarayana Kamath, Revathi T N.

Abstract
Background: Tinea corporis is a common dermatophytic infection affecting 22-25% of the world population. Clotrimazole is conventional antifungal drug whereas sertaconazole is newer antifungal claimed to be superior to clotrimazole. Both are used topically.

Aims and Objective: To compare the efficacy and safety of topical clotrimazole versus sertaconazole in tinea corporis/cruris.

Materials and Methods: A total of 60 patients diagnosed with tinea corporis/cruris were randomized into two groups of 30 patients each. Group A received topical clotrimazole (1% cream), and Group B received topical sertaconazole (2% cream). The patients were advised to apply the drug on affected area twice daily for 4 weeks. Outcome parameters such as pruritus, erythema, vesicles and desquamation, and potassium hydroxide mount were noted weekly for the assessment of efficacy.

Results: There was significant reduction in pruritus (P < 0.001), erythema (P < 0.001), vesicles (P < 0.001), and desquamation (P < 0.001) among both the groups. The mean difference and the standard deviation of the total score of all parameters (baseline to 4th week follow-up) for clotrimazole group were 6.39 ± 1.123 and for sertaconazole group were 7.37 ± 0.751, respectively. The P value on the application of students unpaired t-test was P = 0.115 (not significant). No serious adverse drug events in both the groups.

Conclusion: Clotrimazole is as efficacious and safe as compared with sertaconazole in the treatment of tinea corporis/cruris. However, sertaconazole group has showed an early response to therapy compared to clotrimazole group.

Key words: Sertaconazole; Clotrimazole; Tinea Corporis/Cruris; Potassium Hydroxide

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Pubmed Style

Satish G R, Laxminarayana Kamath, Revathi T N. Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 674-678. doi:10.5455/njppp.2017.7.0102027022017

Web Style

Satish G R, Laxminarayana Kamath, Revathi T N. Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris. https://www.njppp.com/?mno=257201 [Access: March 14, 2024]. doi:10.5455/njppp.2017.7.0102027022017

AMA (American Medical Association) Style

Satish G R, Laxminarayana Kamath, Revathi T N. Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 674-678. doi:10.5455/njppp.2017.7.0102027022017

Vancouver/ICMJE Style

Satish G R, Laxminarayana Kamath, Revathi T N. Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris. Natl J Physiol Pharm Pharmacol. (2017), [cited March 14, 2024]; 7(7): 674-678. doi:10.5455/njppp.2017.7.0102027022017

Harvard Style

Satish G R, Laxminarayana Kamath, Revathi T N (2017) Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris. Natl J Physiol Pharm Pharmacol, 7 (7), 674-678. doi:10.5455/njppp.2017.7.0102027022017

Turabian Style

Satish G R, Laxminarayana Kamath, Revathi T N. 2017. Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 674-678. doi:10.5455/njppp.2017.7.0102027022017

Chicago Style

Satish G R, Laxminarayana Kamath, Revathi T N. "Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 674-678. doi:10.5455/njppp.2017.7.0102027022017

MLA (The Modern Language Association) Style

Satish G R, Laxminarayana Kamath, Revathi T N. "Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris." National Journal of Physiology, Pharmacy and Pharmacology 7.7 (2017), 674-678. Print. doi:10.5455/njppp.2017.7.0102027022017

APA (American Psychological Association) Style

Satish G R, Laxminarayana Kamath, Revathi T N (2017) Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 674-678. doi:10.5455/njppp.2017.7.0102027022017

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