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Original Research Open Access


Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus

Aishe Parhizkar, Farzaneh Ganji, Zahra Nazari, Hamid Sepehri.

Abstract
Background: Filgrastim is a granulocyte colony-stimulating factor (G-CSF), which also showed effects on memory and cognation. Although recent studies have begun to explore G-CSF-related mechanisms of action in memory, little is known about its effects on cholinergic system. Since the cholinergic system has a key role in memory and some studies reported effects of G-CSF on cholinergic activity. Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) gene expression was examined in the rat frontal cortex and hippocampus.

Aims and Objectives: This study was designed to investigate the effect of G-CSF treatment on gene expression of AChE and ChAT in the frontal cortex and hippocampus during learning.

Materials and Methods: In this study, male Wistar rats were treated for 2 week with filgrastim intraperitoneally at doses of 10, 50, 70 μg/kg/day. All rats received Morris water maze training (4 trials/day for 5 days). Moreover, ChAT and AChE gene expression was assessed by real-time polymerase chain reaction in the rat frontal cortex and hippocampus.

Results: Over 5 days of training, filgrastim at doses 10, 50 and 70 μg/kg/day did not change the gene expression of ChAT and AChE in frontal cortex and hippocampus although at dose of 50 ug/kg a little changes but not significant observed.

Conclusions: The findings observed in this study propose that G-CSF memory enhancer effects doesnt only cholinergic and other mechanism may be involve.

Key words: Acetylcholinesterase; Choline Acetyltransferase; Filgrastim; Granulocyte Colony-stimulating Factor


 
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How to Cite this Article
Pubmed Style

Parhizkar A, Ganji F, Nazari Z, Sepehri H. Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 513-516. doi:10.5455/njppp.2017.7.0100724012017



Web Style

Parhizkar A, Ganji F, Nazari Z, Sepehri H. Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus. www.scopemed.org/?mno=255108 [Access: August 16, 2017]. doi:10.5455/njppp.2017.7.0100724012017



AMA (American Medical Association) Style

Parhizkar A, Ganji F, Nazari Z, Sepehri H. Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 513-516. doi:10.5455/njppp.2017.7.0100724012017



Vancouver/ICMJE Style

Parhizkar A, Ganji F, Nazari Z, Sepehri H. Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus. Natl J Physiol Pharm Pharmacol. (2017), [cited August 16, 2017]; 7(5): 513-516. doi:10.5455/njppp.2017.7.0100724012017



Harvard Style

Parhizkar, A., Ganji, F., Nazari, Z. & Sepehri, H. (2017) Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus. Natl J Physiol Pharm Pharmacol, 7 (5), 513-516. doi:10.5455/njppp.2017.7.0100724012017



Turabian Style

Parhizkar, Aishe, Farzaneh Ganji, Zahra Nazari, and Hamid Sepehri. 2017. Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 513-516. doi:10.5455/njppp.2017.7.0100724012017



Chicago Style

Parhizkar, Aishe, Farzaneh Ganji, Zahra Nazari, and Hamid Sepehri. "Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 513-516. doi:10.5455/njppp.2017.7.0100724012017



MLA (The Modern Language Association) Style

Parhizkar, Aishe, Farzaneh Ganji, Zahra Nazari, and Hamid Sepehri. "Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus." National Journal of Physiology, Pharmacy and Pharmacology 7.5 (2017), 513-516. Print. doi:10.5455/njppp.2017.7.0100724012017



APA (American Psychological Association) Style

Parhizkar, A., Ganji, F., Nazari, Z. & Sepehri, H. (2017) Effects of filgrastim on gene expression of cholinergic system in the rat hippocampus. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 513-516. doi:10.5455/njppp.2017.7.0100724012017



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