Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Open Access

Original Research



A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital

Nanthini R, Mamatha K R, Geeta Shivmurthy, Kavitha.

Abstract
Background: The prevalence of iron deficiency anemia (IDA) is 58% among pregnant women in developing countries. According to the recent national guidelines, intramuscular iron sorbitol citric acid (ISCA) complex is one of the firstline drugs for treating moderate IDA in pregnancy. A novel intravenous preparation, iron sucrose promises to be more effective as it causes faster replenishment of iron stores and rapid rise of hemoglobin (Hb).

Aims and Objective: The aim of this study is to evaluate the efficacy and safety of iron sucrose versus ISCA complex in IDA of pregnant women.

Materials and Methods: A total of 127 pregnant women whose Hb between 7 and 9 g/dl were recruited in the study. They were randomized into two groups to receive iron sucrose (intravenous) and ISCA (I.M), respectively. Hematological parameters were measured at baseline, 4 weeks and 8 weeks of treatment. Results: Mean rise in Hb and serum ferritin from baseline was 3.15 0.08 (P < 0.0001) and 14.1 2.6 (P < 0.0001) at the end of 8 weeks, respectively, with ISCA. Mean rise in Hb and serum ferritin from baseline was 3.36 0.06 (P < 0.0001) and 16.28 3.1 (P < 0.0001) at the end of 8 weeks with iron sucrose. 18% and 42% of pregnant women in iron sucrose and ISCA group experienced side effects, respectively.

Conclusion: The rise in hemoglobin and serum ferritin was significant in iron sucrose group with fewer adverse effects. Hence, iron sucrose can be a safe and effective agent in the treatment of IDA in pregnancy.

Key words: Iron Deficiency Anemia; Pregnant Women; Iron Sucrose; Iron Sorbitol Citric Acid Complex


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Nanthini R
Articles by Mamatha K R
Articles by Geeta Shivmurthy
Articles by Kavitha
on Google
on Google Scholar
Article Statistics
 Viewed: 375
Downloaded: 55
Cited: 0


How to Cite this Article
Pubmed Style

R N, R MK, Shivmurthy G, . A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 545-551. doi:10.5455/njppp.2017.7.0100229012017



Web Style

R N, R MK, Shivmurthy G, . A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital. www.scopemed.org/?mno=254631 [Access: May 26, 2017]. doi:10.5455/njppp.2017.7.0100229012017



AMA (American Medical Association) Style

R N, R MK, Shivmurthy G, . A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 545-551. doi:10.5455/njppp.2017.7.0100229012017



Vancouver/ICMJE Style

R N, R MK, Shivmurthy G, . A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2017), [cited May 26, 2017]; 7(5): 545-551. doi:10.5455/njppp.2017.7.0100229012017



Harvard Style

R, N., R, M. K., Shivmurthy, G. & (2017) A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 7 (5), 545-551. doi:10.5455/njppp.2017.7.0100229012017



Turabian Style

R, Nanthini, Mamatha K R, Geeta Shivmurthy, and Kavitha. 2017. A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 545-551. doi:10.5455/njppp.2017.7.0100229012017



Chicago Style

R, Nanthini, Mamatha K R, Geeta Shivmurthy, and Kavitha. "A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 545-551. doi:10.5455/njppp.2017.7.0100229012017



MLA (The Modern Language Association) Style

R, Nanthini, Mamatha K R, Geeta Shivmurthy, and Kavitha. "A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 7.5 (2017), 545-551. Print. doi:10.5455/njppp.2017.7.0100229012017



APA (American Psychological Association) Style

R, N., R, M. K., Shivmurthy, G. & (2017) A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 545-551. doi:10.5455/njppp.2017.7.0100229012017



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Medicus for SEAR

CAB abstract/Global Health

 

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.