Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Original Research Open Access


Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome

Jayanthi C R, Ankita Bedwal, Kavitha Rajarathna.

Abstract
Background: Cutaneous adverse drug reactions (CADRs) are frequent manifestations of drug reactions that can lead to discontinuation of treatment, impaired quality of life and increased economic burden. Knowledge of drugs causing CADRs help in choosing safer drugs.

Aims and Objectives: To determine the clinical spectrum, causality, severity, and preventability of CADRs.

Materials and Methods: An observational study conducted from 2012 to 2016 to analyze the CADRs reported from Dermatology Department, of Bangalore Medical College and Research Institute to adverse drug reaction (ADR) Monitoring Center. Patient’s demographics, clinical and drug data, details of ADRs were collected as per CDSCO form. Causality, severity, and preventability were assessed using relevant scales.

Results: Out of 809 ADRs reported, 230 were CADRs. Male preponderance (56%) was seen. Age group of 21-40 years (57%) was most affected. Maximum CADRs were seen with beta-lactam class of drugs (20%), followed by nonsteroidal anti-inflammatory drugs (17.4%) and antiepileptics (13.5%). Maculopapular rash (26%) was the most common CADR. Stevens–Johnson syndrome (SJS) contributed to the majority of severe CADRs. Causative drug was withdrawn in 90% of cases. Causality assessment indicated 80.4% as probable and 19.6% as possible cases. 81% of CADRs were of moderate severity, and only 6% were severe like SJS. 11% were “definitely preventable” CADRs.

Conclusion: Wide clinical spectrum of CADRs was observed. Definitely preventable CADRs were due to improper recording of history of drug allergy and wrong choice of self-medication by the patients. Inconsistent with the previous literature, the incidence of diclofenac-induced SJS was found high.

Key words: Cutaneous Adverse Drug Reactions; Causality; Severity; Preventability


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Jayanthi C R
Articles by Ankita Bedwal
Articles by Kavitha Rajarathna
on Google
on Google Scholar
Article Statistics
 Viewed: 835
Downloaded: 136
Cited: 0


How to Cite this Article
Pubmed Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 476-481. doi:10.5455/njppp.2017.7.1235625122016



Web Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. www.scopemed.org/?mno=253559 [Access: August 16, 2017]. doi:10.5455/njppp.2017.7.1235625122016



AMA (American Medical Association) Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 476-481. doi:10.5455/njppp.2017.7.1235625122016



Vancouver/ICMJE Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol. (2017), [cited August 16, 2017]; 7(5): 476-481. doi:10.5455/njppp.2017.7.1235625122016



Harvard Style

R, J. C., Bedwal, A. & Rajarathna, K. (2017) Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol, 7 (5), 476-481. doi:10.5455/njppp.2017.7.1235625122016



Turabian Style

R, Jayanthi C, Ankita Bedwal, and Kavitha Rajarathna. 2017. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 476-481. doi:10.5455/njppp.2017.7.1235625122016



Chicago Style

R, Jayanthi C, Ankita Bedwal, and Kavitha Rajarathna. "Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 476-481. doi:10.5455/njppp.2017.7.1235625122016



MLA (The Modern Language Association) Style

R, Jayanthi C, Ankita Bedwal, and Kavitha Rajarathna. "Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome." National Journal of Physiology, Pharmacy and Pharmacology 7.5 (2017), 476-481. Print. doi:10.5455/njppp.2017.7.1235625122016



APA (American Psychological Association) Style

R, J. C., Bedwal, A. & Rajarathna, K. (2017) Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 476-481. doi:10.5455/njppp.2017.7.1235625122016



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Copernicus  (ICV 2015: 92.35)

Index Medicus for SEAR

CAB abstract/Global Health

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.