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Original Research 


Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice

Jyothi C H, Latha S, Ramesh H, Sushma H K.

Abstract
Background: Anxiety disorders are most common mental illness, characterized by changes in mood, behavior, somatic function, and cognition. At present, benzodiazepines are most commonly used drugs for treating anxiety and are associated with many side effects. Medicinal plants are inexhaustible source for searching new drug or new activity, with comparatively lower side effects and drug interactions.

Aim and Objectives: The aim of the study was to evaluate the anxiolytic activity of Ajwain oil alone and combination of Diazepam and Ajwain oil (in subthreshold doses), in Swiss albino mice.

Materials and Methods: A total of 24 Swiss albino mice of either sex weighing 20–30 g were included in the study and were divided into four groups of six animals each. Among which, Group 1 (control) received – tween 80 (10 mg/kg), Group 2 (standard) – Diazepam (1 mg/kg), Group 3 (test-1) – Ajwain oil (50 mg/kg), and Group 4 (test-2) – Diazepam (0.5 mg/kg) + Ajwain oil (25 mg/kg). After 60 min of oral administration of drugs, anxiolytic activity was assisted using elevated plus maze (EPM) and Digital Actophotometer.

Results: Statistical analysis was performed using ANOVA, followed by post hoc Tukey’s test. Ajwain oil showed significant increase in number of entries and time spent in open arm in EPM and in Digital Actophotometer there was decrease in locomotor activity when compared to control. In Group 4, where we used subthreshold dose of Ajwain oil and diazepam, number of entries in EPM and decrease in locomotor activity in Actophotometer showed significant results when compared to standard.

Conclusion: Hence, with the above results, we suggest Ajwain oil possesses significant anxiolytic activity.

Key words: Ajwain Oil; Diazepam; Anxiolytic Activity


 
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How to Cite this Article
Pubmed Style

H JC, S L, H R, K SH. Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2021; 11(4): 389-392. doi:10.5455/njppp.2021.11.12352202012122020


Web Style

H JC, S L, H R, K SH. Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice. http://www.njppp.com/?mno=24803 [Access: April 01, 2021]. doi:10.5455/njppp.2021.11.12352202012122020


AMA (American Medical Association) Style

H JC, S L, H R, K SH. Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2021; 11(4): 389-392. doi:10.5455/njppp.2021.11.12352202012122020



Vancouver/ICMJE Style

H JC, S L, H R, K SH. Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice. Natl J Physiol Pharm Pharmacol. (2021), [cited April 01, 2021]; 11(4): 389-392. doi:10.5455/njppp.2021.11.12352202012122020



Harvard Style

H, J. C., S, . L., H, . R. & K, . S. H. (2021) Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice. Natl J Physiol Pharm Pharmacol, 11 (4), 389-392. doi:10.5455/njppp.2021.11.12352202012122020



Turabian Style

H, Jyothi C, Latha S, Ramesh H, and Sushma H K. 2021. Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 11 (4), 389-392. doi:10.5455/njppp.2021.11.12352202012122020



Chicago Style

H, Jyothi C, Latha S, Ramesh H, and Sushma H K. "Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 389-392. doi:10.5455/njppp.2021.11.12352202012122020



MLA (The Modern Language Association) Style

H, Jyothi C, Latha S, Ramesh H, and Sushma H K. "Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 11.4 (2021), 389-392. Print. doi:10.5455/njppp.2021.11.12352202012122020



APA (American Psychological Association) Style

H, J. C., S, . L., H, . R. & K, . S. H. (2021) Evaluation of anxiolytic activity of Trachyspermum ammi (ajwain oil) in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 11 (4), 389-392. doi:10.5455/njppp.2021.11.12352202012122020