Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy

Payal P Naik; Chaitali D Mehta; Sachendra K Srivastava

doi:10.5455/njppp.2017.7.1029421112016

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Online Publishing Date:
02 / 12 / 2016

Natl J Physiol Pharm Pharmacol. 2017; 7(4): 348-354

doi: 10.5455/njppp.2017.7.1029421112016

Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava.

Abstract
Background: Antibiotics are frequently prescribed medication. When drugs are dispensed in form of syrups or suspensions, appropriate volume should be dispensed in a bottle otherwise, it may result into wastage of drug, inadequate treatment, and resistance and also increased cost of treatment.

Aims and Objective: The aim of our study was to analyze systemic antibacterial liquid formulations to ascertain the availability of adequate strength, volume dispensed for adequate treatment.

Materials and Methods: The commonly available (IDR triple, Issue 2, 2016) oral liquid antibacterial formulations were analyzed. According to the weight of child (for 12 and 18 kg), amount of drug and requirement of number of bottles for 5 days were calculated.

Results: Majority of manufacturers have dispensed inadequate volume of antibacterial drugs which was not sufficient for one course of therapy. For example, most of the formulations of cephalexin, cefixime, cefpodoxime, and amoxicillin + clavulanic acid were available in dispensing volume of 30 ml. This results into inadequate dose, wastage of drug (residual volume), resistance, and unnecessary social and financial burden to the patient. Hence, more number of bottles shall be required to complete a course of antibiotic.

Conclusion: The dispensing volume of oral liquid dosage forms of most of the formulations were inadequate and thus, minimum amount dispensed should be 60 ml or as applicable for an antibiotic.

Key words: Antibiotics; Formulations; Pediatrics; Suspensions; Syrup

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Pubmed Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava. Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy. Natl J Physiol Pharm Pharmacol. 2017; 7(4): 348-354. doi:10.5455/njppp.2017.7.1029421112016

Web Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava. Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy. https://www.njppp.com/?mno=244808 [Access: March 15, 2024]. doi:10.5455/njppp.2017.7.1029421112016

AMA (American Medical Association) Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava. Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy. Natl J Physiol Pharm Pharmacol. 2017; 7(4): 348-354. doi:10.5455/njppp.2017.7.1029421112016

Vancouver/ICMJE Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava. Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy. Natl J Physiol Pharm Pharmacol. (2017), [cited March 15, 2024]; 7(4): 348-354. doi:10.5455/njppp.2017.7.1029421112016

Harvard Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava (2017) Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy. Natl J Physiol Pharm Pharmacol, 7 (4), 348-354. doi:10.5455/njppp.2017.7.1029421112016

Turabian Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava. 2017. Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy. National Journal of Physiology, Pharmacy and Pharmacology, 7 (4), 348-354. doi:10.5455/njppp.2017.7.1029421112016

Chicago Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava. "Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 348-354. doi:10.5455/njppp.2017.7.1029421112016

MLA (The Modern Language Association) Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava. "Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy." National Journal of Physiology, Pharmacy and Pharmacology 7.4 (2017), 348-354. Print. doi:10.5455/njppp.2017.7.1029421112016

APA (American Psychological Association) Style

Payal P Naik, Chaitali D Mehta, Sachendra K Srivastava (2017) Analysis of commonly used pediatric systemic antibacterial liquid formulations for rational drug therapy. National Journal of Physiology, Pharmacy and Pharmacology, 7 (4), 348-354. doi:10.5455/njppp.2017.7.1029421112016

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