E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus

Shilalipi Pradhan, Aurobinda Chinara, Bimal Kumar Sahoo.

Abstract
Background: Diabetes mellitus (DM) is characterized by chronic hyperglycemia resulting in micro- and macro-vascular complications and is correlated with glycemic control and its duration. The undergoing pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Mean platelet volume (MPV) is a simple economical test in the monitoring of DM.

Aims and Objectives: This study aims to determine the activation of platelets in diabetes by measuring the MPV in non-diabetic and diabetic subjects, respectively and to find out the correlation of MPV with blood glucose level.

Materials and Methods: It was a cross-sectional study conducted on 70 previously diagnosed diabetic and 130 non-diabetic patients using convenient sampling in SCB Medical College, Odisha. Blood parameters such as body mass index (BMI), fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), and MPV were recorded from complete blood count and compared using independent sample t-test and Pearson correlation test.

Results: Mean age of the diabetic population was 53.7 ± 10.63 years. Positive correlation was found between MPV and BMI, FBS, PPBS, and HbA1c. The mean MPV in Group A was significantly lower than that of Group B.

Conclusion: MPV in Type 2 DM was significantly elevated and positively correlated to blood glucose level. Thus, strict glycemic control measures should be advised to patients with DM for halting the progression of complications in them.

Key words: Mean Platelet Volume; Diabetes Mellitus; Platelet Activation


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shilalipi Pradhan
Articles by Aurobinda Chinara
Articles by Bimal Kumar Sahoo
on Google
on Google Scholar
Article Statistics
 Viewed: 570
Downloaded: 117
Cited: 0

How to Cite this Article
Pubmed Style

Pradhan S, Chinara A, Sahoo BK. Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 243-247. doi:10.5455/njppp.2019.9.0100117012019


Web Style

Pradhan S, Chinara A, Sahoo BK. Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus. http://www.njppp.com/?mno=24211 [Access: March 25, 2019]. doi:10.5455/njppp.2019.9.0100117012019


AMA (American Medical Association) Style

Pradhan S, Chinara A, Sahoo BK. Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 243-247. doi:10.5455/njppp.2019.9.0100117012019



Vancouver/ICMJE Style

Pradhan S, Chinara A, Sahoo BK. Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. (2019), [cited March 25, 2019]; 9(3): 243-247. doi:10.5455/njppp.2019.9.0100117012019



Harvard Style

Pradhan, S., Chinara, . A. & Sahoo, . B. K. (2019) Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus. Natl J Physiol Pharm Pharmacol, 9 (3), 243-247. doi:10.5455/njppp.2019.9.0100117012019



Turabian Style

Pradhan, Shilalipi, Aurobinda Chinara, and Bimal Kumar Sahoo. 2019. Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 243-247. doi:10.5455/njppp.2019.9.0100117012019



Chicago Style

Pradhan, Shilalipi, Aurobinda Chinara, and Bimal Kumar Sahoo. "Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 243-247. doi:10.5455/njppp.2019.9.0100117012019



MLA (The Modern Language Association) Style

Pradhan, Shilalipi, Aurobinda Chinara, and Bimal Kumar Sahoo. "Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus." National Journal of Physiology, Pharmacy and Pharmacology 9.3 (2019), 243-247. Print. doi:10.5455/njppp.2019.9.0100117012019



APA (American Psychological Association) Style

Pradhan, S., Chinara, . A. & Sahoo, . B. K. (2019) Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 243-247. doi:10.5455/njppp.2019.9.0100117012019





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Effectiveness of “case-based learning” in physiology
    Amruta S Bennal, Manohar Y Pattar, Raju H Taklikar
    Natl J Physiol Pharm Pharmacol. 2016; 6(1): 65-67
    » Abstract & References » doi: 10.5455/njppp.2015.5.1810201583

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Most Cited Articles
  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 10 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 9 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 6 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 5 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 5 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 5 times [Click to see citing articles]

  • Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation
    Rasha R Ahmed, Ayman M Mahmoud, Mohamed B Ashour, Amira M Kamel
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 391-397
    » Abstract & References » doi: 10.5455/njppp.2015.5.2907201567
    Cited : 5 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]