E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats

Sudha Madhuri A, Roopa C R.

Abstract
Background: Hibiscus rosa sinensis which belongs to family Malvaceae is traditionally used in various diseases due to its medicinal properties. Most of the uses were studied in detail by many researchers, but the studies evaluating the skeletal muscle relaxant activity of H. rosa sinensis leaves are limited.

Aims and Objectives: The present study was undertaken to evaluate the skeletal muscle relaxant activity of the methanolic extract of H. rosa sinensis leaves (MEHRL) in albino rats.

Materials and Methods: MEHRL was prepared and tested for skeletal muscle relaxant activity in albino rats weighing 200–250 g. The animals were divided into four different groups. Group I (control) received normal saline 10 ml/kg, Group II (standard) received diazepam 10 mg/kg, and Groups III and IV received MEHRL 200 mg/kg and 400 mg/kg body weight, respectively. Skeletal muscle relaxant activity (motor coordination) on rotarod and locomotor activity on photoactometer was performed. Statistical analysis was carried out using analysis of variance, followed by Dunnett’s multiple comparison tests.

Results: The results from the actophotometer and rotarod test showed that MEHRL significantly reduced the motor coordination and locomotor activity of tested animal.

Conclusion: MEHRL showed significant dose-dependent skeletal muscle relaxant activity.

Key words: Actophotometer; Hibiscus rosa sinensis; Rotarod; Skeletal Muscle Relaxant


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sudha Madhuri A
Articles by Roopa C R
on Google
on Google Scholar
Article Statistics
 Viewed: 1097
Downloaded: 333
Cited: 0


How to Cite this Article
Pubmed Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 206-209. doi:10.5455/njppp.2019.9.1237703012019


Web Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. http://www.njppp.com/?mno=23169 [Access: May 27, 2019]. doi:10.5455/njppp.2019.9.1237703012019


AMA (American Medical Association) Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 206-209. doi:10.5455/njppp.2019.9.1237703012019



Vancouver/ICMJE Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol. (2019), [cited May 27, 2019]; 9(3): 206-209. doi:10.5455/njppp.2019.9.1237703012019



Harvard Style

A, S. M. & R, . R. C. (2019) Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol, 9 (3), 206-209. doi:10.5455/njppp.2019.9.1237703012019



Turabian Style

A, Sudha Madhuri, and Roopa C R. 2019. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 206-209. doi:10.5455/njppp.2019.9.1237703012019



Chicago Style

A, Sudha Madhuri, and Roopa C R. "Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 206-209. doi:10.5455/njppp.2019.9.1237703012019



MLA (The Modern Language Association) Style

A, Sudha Madhuri, and Roopa C R. "Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 9.3 (2019), 206-209. Print. doi:10.5455/njppp.2019.9.1237703012019



APA (American Psychological Association) Style

A, S. M. & R, . R. C. (2019) Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 206-209. doi:10.5455/njppp.2019.9.1237703012019





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Comparison of bleeding time and clotting time between males and females
    Ritu Adhana, Rajanish Chaurasiya, Anjali Verma
    Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1388-1390
    » Abstract » doi: 10.5455/ijmsph.2018.06201417062018

  • Effectiveness of “case-based learning” in physiology
    Amruta S Bennal, Manohar Y Pattar, Raju H Taklikar
    Natl J Physiol Pharm Pharmacol. 2016; 6(1): 65-67
    » Abstract & References » doi: 10.5455/njppp.2015.5.1810201583

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Most Cited Articles
  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 10 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 9 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 6 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 5 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 5 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 5 times [Click to see citing articles]

  • Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation
    Rasha R Ahmed, Ayman M Mahmoud, Mohamed B Ashour, Amira M Kamel
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 391-397
    » Abstract & References » doi: 10.5455/njppp.2015.5.2907201567
    Cited : 5 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]