Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats

Sudha Madhuri A; Roopa C R

doi:10.5455/njppp.2019.9.1237703012019

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28 / 01 / 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(3): 206-209

doi: 10.5455/njppp.2019.9.1237703012019

Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats

Sudha Madhuri A, Roopa C R.

Abstract
Background: Hibiscus rosa sinensis which belongs to family Malvaceae is traditionally used in various diseases due to its medicinal properties. Most of the uses were studied in detail by many researchers, but the studies evaluating the skeletal muscle relaxant activity of H. rosa sinensis leaves are limited.

Aims and Objectives: The present study was undertaken to evaluate the skeletal muscle relaxant activity of the methanolic extract of H. rosa sinensis leaves (MEHRL) in albino rats.

Materials and Methods: MEHRL was prepared and tested for skeletal muscle relaxant activity in albino rats weighing 200250 g. The animals were divided into four different groups. Group I (control) received normal saline 10 ml/kg, Group II (standard) received diazepam 10 mg/kg, and Groups III and IV received MEHRL 200 mg/kg and 400 mg/kg body weight, respectively. Skeletal muscle relaxant activity (motor coordination) on rotarod and locomotor activity on photoactometer was performed. Statistical analysis was carried out using analysis of variance, followed by Dunnetts multiple comparison tests.

Results: The results from the actophotometer and rotarod test showed that MEHRL significantly reduced the motor coordination and locomotor activity of tested animal.

Conclusion: MEHRL showed significant dose-dependent skeletal muscle relaxant activity.

Key words: Actophotometer; Hibiscus rosa sinensis; Rotarod; Skeletal Muscle Relaxant

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Pubmed Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 206-209. doi:10.5455/njppp.2019.9.1237703012019

Web Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. https://www.njppp.com/?mno=23169 [Access: March 14, 2024]. doi:10.5455/njppp.2019.9.1237703012019

AMA (American Medical Association) Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 206-209. doi:10.5455/njppp.2019.9.1237703012019

Vancouver/ICMJE Style

A SM, R RC. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol. (2019), [cited March 14, 2024]; 9(3): 206-209. doi:10.5455/njppp.2019.9.1237703012019

Harvard Style

A, S. M. & R, . R. C. (2019) Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. Natl J Physiol Pharm Pharmacol, 9 (3), 206-209. doi:10.5455/njppp.2019.9.1237703012019

Turabian Style

A, Sudha Madhuri, and Roopa C R. 2019. Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 206-209. doi:10.5455/njppp.2019.9.1237703012019

Chicago Style

A, Sudha Madhuri, and Roopa C R. "Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 206-209. doi:10.5455/njppp.2019.9.1237703012019

MLA (The Modern Language Association) Style

A, Sudha Madhuri, and Roopa C R. "Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 9.3 (2019), 206-209. Print. doi:10.5455/njppp.2019.9.1237703012019

APA (American Psychological Association) Style

A, S. M. & R, . R. C. (2019) Evaluation of skeletal muscle relaxant activity of methanolic extract of Hibiscus rosa sinensis leaves in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 206-209. doi:10.5455/njppp.2019.9.1237703012019

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