E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
06 / 08 / 2016

 


A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag.


Abstract
Background: The present study is an investigation of antiepileptic activity of Withania somnifera (Ashwagandha) is a well-known plant which is being used in tuberculosis, emaciation, sterility, and it has immunomodulatory, anabolic, anti-inflammatory, and antianxiety activities.

Aims and Objectives: To find the efficacy of the alcoholic extract of W. somnifera (Dunal) in preventing experimentally-induced seizures.

Materials and Methods: The alcoholic extract of W. somnifera was subjected to pilot study and then screened for anticonvulsant activity on maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures models in albino Wistar rats. Animals were treated with W. somnifera at doses of 100 mg/kg, 200 mg/kg, and 300 mg/kg body weight and compared the results with control and standard.

Results: Study results showed that W. somnifera extract at the dose of 300 mg/kg body weight when compared to control group highly significant (P < 0.01) reduction of hindlimb tonic extension and postictal depression in MES. PTZ-induced seizures showed significantly reduced mean duration of hindlimb tonic flexion, hindlimb tonic extension, clonus, and stupor and there was no postictal depression.

Conclusions: The alcoholic extract of W. somnifera (Dunal) has shown a significant anticonvulsant effect at the dose of 300 mg/kg body weight, both in MES method and PTZ method and has given higher protection rate against pentylenetetrazol seizure than MES.

Key words: Withania somnifera; Pentylenetetrazole; Maximal Electroshock Model


 
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How to Cite this Article
Pubmed Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag. A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 17-21. doi:10.5455/njppp.2016.6.0615112072016


Web Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag. A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats. https://www.njppp.com/?mno=231582 [Access: March 14, 2024]. doi:10.5455/njppp.2016.6.0615112072016


AMA (American Medical Association) Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag. A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 17-21. doi:10.5455/njppp.2016.6.0615112072016



Vancouver/ICMJE Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag. A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats. Natl J Physiol Pharm Pharmacol. (2017), [cited March 14, 2024]; 7(1): 17-21. doi:10.5455/njppp.2016.6.0615112072016



Harvard Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag (2017) A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats. Natl J Physiol Pharm Pharmacol, 7 (1), 17-21. doi:10.5455/njppp.2016.6.0615112072016



Turabian Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag. 2017. A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 17-21. doi:10.5455/njppp.2016.6.0615112072016



Chicago Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag. "A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 17-21. doi:10.5455/njppp.2016.6.0615112072016



MLA (The Modern Language Association) Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag. "A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 7.1 (2017), 17-21. Print. doi:10.5455/njppp.2016.6.0615112072016



APA (American Psychological Association) Style

Santhosh Kumar Raju, Basavanna PL, Nagesh HN, Ajay D Shanbhag (2017) A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 17-21. doi:10.5455/njppp.2016.6.0615112072016