E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
28 / 07 / 2016

 


Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age

Sonunbu Sh. Sulaimanova.


Abstract
Background: The paper presents the data on a condition and a role of inflammation mediators and the antioxidant protection system in blood plasma for endometriosis genitalis (EG) in women of reproductive age. The material for the research included results from the survey of 104 women of reproductive age, divided into two groups (control group and clinical group). It is shown in the paper that EG occurs with the development of oxidative stress (OS) caused by activation of lipid peroxidation and the cytokine system with a simultaneous reduction in the antioxidant defense system.

Aims and Objective: To define the condition and the role of inflammation mediators of lipid and cytokine natures and the antioxidant protection system in the development of EG in women of reproductive age.

Materials and Methods: The research was carried out among 104 women of reproductive age, divided into control and clinical groups. The clinical groups included women with adenomyosis and EG externa. EG was verified with clinical findings, ultrasound examinations of pelvic organs, hysteroscopies, and diagnostic laparoscopies. Statistik, version 6.0, was used for statistical analysis. Diagnostic techniques included spectrophotometric, biochemical, and enzyme immunodetection methods.

Results: Imbalance between radical processes and antioxidant protection systems causes the development of OS for EG; imbalance between pro-inflammatory and anti-inflammatory cytokines leads to inflammation activation and increased activities of triggers that develop endometrioid focuses.

Conclusion: Due to unclear mechanisms of its development, EG is problematic in its respond to treatment while the OS contribution into the pathophysiological basis is highly reasonable. Components of menstrual blood are triggers for OS. With failed mechanisms in the cleansing system, the macrophage reaction gets stronger followed by a release of cytokines.

Key words: Endometriosis Genitalis; Oxidative Stress; Lipid Peroxidation; Antioxidant Protection System; Cytokines; Interleukins


 
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Pubmed Style

Sonunbu Sh. Sulaimanova. Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 13-16. doi:10.5455/njppp.2016.6.0615220072016


Web Style

Sonunbu Sh. Sulaimanova. Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age. https://www.njppp.com/?mno=231391 [Access: March 14, 2024]. doi:10.5455/njppp.2016.6.0615220072016


AMA (American Medical Association) Style

Sonunbu Sh. Sulaimanova. Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 13-16. doi:10.5455/njppp.2016.6.0615220072016



Vancouver/ICMJE Style

Sonunbu Sh. Sulaimanova. Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age. Natl J Physiol Pharm Pharmacol. (2017), [cited March 14, 2024]; 7(1): 13-16. doi:10.5455/njppp.2016.6.0615220072016



Harvard Style

Sonunbu Sh. Sulaimanova (2017) Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age. Natl J Physiol Pharm Pharmacol, 7 (1), 13-16. doi:10.5455/njppp.2016.6.0615220072016



Turabian Style

Sonunbu Sh. Sulaimanova. 2017. Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 13-16. doi:10.5455/njppp.2016.6.0615220072016



Chicago Style

Sonunbu Sh. Sulaimanova. "Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 13-16. doi:10.5455/njppp.2016.6.0615220072016



MLA (The Modern Language Association) Style

Sonunbu Sh. Sulaimanova. "Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age." National Journal of Physiology, Pharmacy and Pharmacology 7.1 (2017), 13-16. Print. doi:10.5455/njppp.2016.6.0615220072016



APA (American Psychological Association) Style

Sonunbu Sh. Sulaimanova (2017) Condition of inflammation mediators and antioxidant protection system for endometriosis genitalis in women of reproductive age. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 13-16. doi:10.5455/njppp.2016.6.0615220072016