E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 4
14 / 4Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Authorship Declaration

Case Report

Online Publishing Date:
23 / 06 / 2016

 


Drug reaction with eosinophilia and systemic symptoms for phenytoin

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas.


Abstract
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity syndrome characterized by fever, skin eruptions, hematologic abnormalities, and systemic involvement frequently reported with anticonvulsants, allopurinol, nevirapine, and sulfasalazine. We report a case of DRESS syndrome in a patient with neurocysticercosis receiving phenytoin. A 60-year-old male patient was diagnosed with seizures due to neurocysticercosis and was prescribed phenytoin. 2 weeks after therapy, the patient had fever, burning micturition, decreased appetite, and generalized weakness for which he was treated symptomatically by a local practitioner. 2 days later, fever had recurred with generalized cutaneous hyperemia which was treated with antimicrobials in a local hospital, as it did not resolve patient was referred to our hospital. The findings on examination were icterus, periorbital edema, oral mucositis, facial puffiness, and generalized maculopapular rashes. Eosinophils, erythrocyte sedimentation rate, and liver enzymes were elevated, abdominal scan revealed hepatomegaly and cystitis. It was diagnosed as DRESS and phenytoin were discontinued. He was treated with corticosteroids. There was a clinical improvement, and liver function test was normal after a month. DRESS is a Type IV delayed hypersensitivity reaction which manifests after 2-4 weeks of treatment with an offending agent. This report indicates that the occurrence of DRESS has a higher preponderance in patients receiving phenytoin for seizures due to neurocysticercosis.

Key words: Phenytoin; Neurocysticercosis; Drug Reaction with Eosinophilia and Systemic Symptoms


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sowmya Chinnaiyan
Articles by Bhuvana Krishnaswamy
Articles by Sarala Narayana
Articles by Rajashekar Talari Srinivas
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas. Drug reaction with eosinophilia and systemic symptoms for phenytoin. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 634-636. doi:10.5455/njppp.2016.6.0614809062016

Web Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas. Drug reaction with eosinophilia and systemic symptoms for phenytoin. https://www.njppp.com/?mno=231175 [Access: March 17, 2024]. doi:10.5455/njppp.2016.6.0614809062016

AMA (American Medical Association) Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas. Drug reaction with eosinophilia and systemic symptoms for phenytoin. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 634-636. doi:10.5455/njppp.2016.6.0614809062016


Vancouver/ICMJE Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas. Drug reaction with eosinophilia and systemic symptoms for phenytoin. Natl J Physiol Pharm Pharmacol. (2016), [cited March 17, 2024]; 6(6): 634-636. doi:10.5455/njppp.2016.6.0614809062016


Harvard Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas (2016) Drug reaction with eosinophilia and systemic symptoms for phenytoin. Natl J Physiol Pharm Pharmacol, 6 (6), 634-636. doi:10.5455/njppp.2016.6.0614809062016


Turabian Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas. 2016. Drug reaction with eosinophilia and systemic symptoms for phenytoin. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 634-636. doi:10.5455/njppp.2016.6.0614809062016


Chicago Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas. "Drug reaction with eosinophilia and systemic symptoms for phenytoin." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 634-636. doi:10.5455/njppp.2016.6.0614809062016


MLA (The Modern Language Association) Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas. "Drug reaction with eosinophilia and systemic symptoms for phenytoin." National Journal of Physiology, Pharmacy and Pharmacology 6.6 (2016), 634-636. Print. doi:10.5455/njppp.2016.6.0614809062016


APA (American Psychological Association) Style

Sowmya Chinnaiyan, Bhuvana Krishnaswamy, Sarala Narayana, Rajashekar Talari Srinivas (2016) Drug reaction with eosinophilia and systemic symptoms for phenytoin. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 634-636. doi:10.5455/njppp.2016.6.0614809062016


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

  National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Publisher

publishernjppp@gmail.com

 

Editorial query

editornjppp1@gmail.com

MOB - 8780040272