E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis

Sohil P Makwana, Manish N Solanki, Ram K Dikshit.

Abstract
Background: Complicated urinary tract infections (cUTIs) are one of the leading causes of the Gram-negative bacteremia which commonly seen in patients who have a functionally, metabolically, or anatomically abnormal urinary tract. In patients with cUTI, proper treatment can reduce the unnecessary rick and cost of disease progression.

Aims and Objectives: The aim of the study was to compare efficacy and safety Cefoperazone + Sulbactam (CPS) versus Cefotaxime + Sulbactam (CTS) combinations in cUTI.

Materials and Methods: At entry, a total of 74 patients admitted in the hospital due to cUTI were enrolled. Among 74 patients, 43 patients were given CPS while 31 patients were given CTS combinations. Five clinical symptoms (e.g., dysuria, frequency, suprapubic pain, back, and/or flank pain) were registered and scored as mild (1), moderate (2), or severe (3). The follow-up of the indoor patients was done daily until the patient is discharged. Thereafter, one follow-up visit was done within 4–9 days of after discharge, termed as a test of cure (TOC). Furthermore, one late follow-up visit (LFU) after 6–8 weeks was done, known as LFU. Clinical assessments and microbiological analysis were done at the time of TOC and LFU. The mean baseline clinical score for CPS and CTS was 10.28 ± 2.33 and 10.57 ± 2.02, respectively. Results: At TOC visit, in CPS and CTS groups, clinical scores were 1.36 ± 3.48 and 1.25 ± 3.47 in CPS and CTS, respectively, suggesting significant improvement from baseline (P < 0.005). Rate of clinical improvement at TOC visit was 87.50% and 92.00% while microbiological cure rate was 93.75% and 84.00% with CPS and CTS groups, respectively, while, at LFU visit, clinical scores in both groups were 1.65 ± 4.10 and 1.30 ± 3.56 suggesting significant improvement from baseline (P < 0.005). Clinical cure rate at LFU visit was 87.85% and 88.00% while microbiological cure rate at LFU visit was 77.00% and 76.00% with CPS and CTS groups, respectively.

Conclusion: These results suggest that both regimens have no significant difference in the treatment of cUTI. The study concluded that both the combination, CTS and CTS are equally efficacious in the treatment of cUTI. The frequency and severity of drug-related adverse events were generally similar in both treatment groups.

Key words: Urinary tract infections; Cefoperazone; Sulbactam; Cefotaxime; Complicated urinary tract infections


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sohil P Makwana
Articles by Manish N Solanki
Articles by Ram K Dikshit
on Google
on Google Scholar
Article Statistics
 Viewed: 407
Downloaded: 96
Cited: 0

How to Cite this Article
Pubmed Style

Makwana SP, Solanki MN, Dikshit RK. Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 187-195. doi:10.5455/njppp.2019.9.1236526122018


Web Style

Makwana SP, Solanki MN, Dikshit RK. Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis. http://www.njppp.com/?mno=21456 [Access: February 15, 2019]. doi:10.5455/njppp.2019.9.1236526122018


AMA (American Medical Association) Style

Makwana SP, Solanki MN, Dikshit RK. Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 187-195. doi:10.5455/njppp.2019.9.1236526122018



Vancouver/ICMJE Style

Makwana SP, Solanki MN, Dikshit RK. Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis. Natl J Physiol Pharm Pharmacol. (2019), [cited February 15, 2019]; 9(2): 187-195. doi:10.5455/njppp.2019.9.1236526122018



Harvard Style

Makwana, S. P., Solanki, . M. N. & Dikshit, . R. K. (2019) Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis. Natl J Physiol Pharm Pharmacol, 9 (2), 187-195. doi:10.5455/njppp.2019.9.1236526122018



Turabian Style

Makwana, Sohil P, Manish N Solanki, and Ram K Dikshit. 2019. Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 187-195. doi:10.5455/njppp.2019.9.1236526122018



Chicago Style

Makwana, Sohil P, Manish N Solanki, and Ram K Dikshit. "Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 187-195. doi:10.5455/njppp.2019.9.1236526122018



MLA (The Modern Language Association) Style

Makwana, Sohil P, Manish N Solanki, and Ram K Dikshit. "Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis." National Journal of Physiology, Pharmacy and Pharmacology 9.2 (2019), 187-195. Print. doi:10.5455/njppp.2019.9.1236526122018



APA (American Psychological Association) Style

Makwana, S. P., Solanki, . M. N. & Dikshit, . R. K. (2019) Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: Safety and efficacy analysis. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 187-195. doi:10.5455/njppp.2019.9.1236526122018





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20

  • Most Cited Articles
  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 9 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 8 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 5 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 5 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8
    Cited : 4 times [Click to see citing articles]

  • Effects of sixteen weeks exercise training on left ventricular dimensions and function in young athletes
    Sandip M Hulke, Yuganti P Vaidya, Amandeepkour R Ratta
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 152-158
    » Abstract & References » doi: 10.5455/njppp.2012.2.152-158
    Cited : 4 times [Click to see citing articles]

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138
    Cited : 4 times [Click to see citing articles]