E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice

Ainun Naim, Mevy Trisna, Mhd Riza Marjoni.

Abstract
Background: Traditional usage and many studies show that leaves salam and leaves bitter on a single use have an antidiabetic effect.

Aims and Objectives: The aim of this research is to know the combination of aqueous extract of salam leaves and bitter leaves in decreasing blood glucose level in white male mice-induced alloxan using pre-test and post-test group control design.

Materials and Methods: White male mice are grouped into six treatment groups: Normal control, negative controls (CMC-Na 0,5%), positive control (metformin HCl dose of 20 mg/KgBW), SB 7,5:20, SB 15:40, and SB 30:80. All groups except normal control-induced alloxan dose of 200 mg/KgBW on day-0, treatment continued from day 1–day 24. The data obtained were blood glucose level of mice before and after treatment. Blood glucose level data were analyzed using Shapiro–Wilk test and continued by analysis of variance (ANOVA) with α = 0.01.

Results: The results showed that there was a decrease in blood glucose level a combination of aqueous extract salam leaves and bitter leaves at P <0.01.

Conclusion: Combination of aqueous extract salam leaves and bitter leaves is able to lower blood glucose level in male white mice.

Key words: Antidiabetic; Salam Leaves; Bitter Leaves; Aqueous Extract


 
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Pubmed Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1446-1450. doi:10.5455/njppp.2018.8.0724024072018


Web Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. http://www.njppp.com/?mno=2132 [Access: October 21, 2018]. doi:10.5455/njppp.2018.8.0724024072018


AMA (American Medical Association) Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1446-1450. doi:10.5455/njppp.2018.8.0724024072018



Vancouver/ICMJE Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol. (2018), [cited October 21, 2018]; 8(10): 1446-1450. doi:10.5455/njppp.2018.8.0724024072018



Harvard Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni (2018) The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol, 8 (10), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018



Turabian Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni. 2018. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018



Chicago Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni. "The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018



MLA (The Modern Language Association) Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni. "The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice." National Journal of Physiology, Pharmacy and Pharmacology 8.10 (2018), 1446-1450. Print. doi:10.5455/njppp.2018.8.0724024072018



APA (American Psychological Association) Style

Ainun Naim| Mevy Trisna| Mhd Riza Marjoni (2018) The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018





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