E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation

Sujoy Mukherjee, Goutam Banerjee, Anil Baran Singha Mahapatra.

Abstract
Background: Long-acting beta-2 agonists (LABA) are recommended for regular use to control chronic lower respiratory symptoms (LRS). However, LABAs may have the potency to modulate the lung pathology by suppressing the ongoing bronchial inflammation, leaving such patients at greater risk of severe complications.

Aims and Objectives: The aim of this study was to evaluate the effect of inhaled LABA medications on small airways in patients with chronic LRS by spirometric screening at a tertiary hospital.

Materials and Methods: A total of 240 urban patients (aged 25–50 years; both genders) with LRS referred from outdoor patients for spirometric screening were included in this study. After obtaining detailed clinical profile, patients were divided into two groups based on inhaled medications history: Lone LABA users (n = 130) and combined bronchodilator (BDRs) regimen (LABA + inhaled corticosteroids) users group (n = 110). Spirometry was carried out following recommendations of the American Thoracic Society/European Respiratory Society (2005). Patients were categorized based on forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, FEF25–75%, and peak expiratory flow rate values.

Results: A study revealed that those patients were treated with lone LABA inhalers chronically, persistence of small airways obstruction was significantly higher in them compared to combined BDRs regimen user group.

Conclusion: The present study explores better efficacy of combined usage of combined BDRs regimen and potential masking effect of lone LABA in small airway diseases with respect to clinicospirometry study.

Key words: Long-acting Beta-2 Agonists; Small Airways Obstruction; Spirometry


 
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Pubmed Style

Mukherjee S, Banerjee G, Mahapatra ABS. Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 165-171. doi:10.5455/njppp.2019.9.1236217122018


Web Style

Mukherjee S, Banerjee G, Mahapatra ABS. Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation. http://www.njppp.com/?mno=21272 [Access: April 25, 2019]. doi:10.5455/njppp.2019.9.1236217122018


AMA (American Medical Association) Style

Mukherjee S, Banerjee G, Mahapatra ABS. Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 165-171. doi:10.5455/njppp.2019.9.1236217122018



Vancouver/ICMJE Style

Mukherjee S, Banerjee G, Mahapatra ABS. Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation. Natl J Physiol Pharm Pharmacol. (2019), [cited April 25, 2019]; 9(2): 165-171. doi:10.5455/njppp.2019.9.1236217122018



Harvard Style

Mukherjee, S., Banerjee, . G. & Mahapatra, . A. B. S. (2019) Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation. Natl J Physiol Pharm Pharmacol, 9 (2), 165-171. doi:10.5455/njppp.2019.9.1236217122018



Turabian Style

Mukherjee, Sujoy, Goutam Banerjee, and Anil Baran Singha Mahapatra. 2019. Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 165-171. doi:10.5455/njppp.2019.9.1236217122018



Chicago Style

Mukherjee, Sujoy, Goutam Banerjee, and Anil Baran Singha Mahapatra. "Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 165-171. doi:10.5455/njppp.2019.9.1236217122018



MLA (The Modern Language Association) Style

Mukherjee, Sujoy, Goutam Banerjee, and Anil Baran Singha Mahapatra. "Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation." National Journal of Physiology, Pharmacy and Pharmacology 9.2 (2019), 165-171. Print. doi:10.5455/njppp.2019.9.1236217122018



APA (American Psychological Association) Style

Mukherjee, S., Banerjee, . G. & Mahapatra, . A. B. S. (2019) Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 165-171. doi:10.5455/njppp.2019.9.1236217122018





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