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Original Research 


Evaluation of the impact of cigarette smoking on platelet parameters

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo.

Cited by (1)

Abstract
Background: Smoking has been established as a chief causative factor for cardiovascular diseases, inflammatory disorders, and oxidative stress stimulation. It is known that the total peripheral blood leukocyte count increases by cigarette smoking; however, its influence on platelet parameters is largely unknown. Early detection of thromboembolic diseases can be achieved by the potentially useful platelet indices. Enhanced activity is shown by platelets with increased volume when compared with platelets with smaller volume. Hence, mean platelet volume (MPV) can act as a indicator for platelet activity.

Aims and Objective: To study the impact of cigarette smoking on platelet parameters.

Materials and Methods: This crosssectional study included 50 healthy young male cigarette smokers and 50 healthy male nonsmokers in the age range of 18–50 years at SRM Medical College, Tamil Nadu, India, after approval by the institutional ethical committee. Subjects with acute illness and diabetes mellitus and those on antiplatelet drugs were excluded. History regarding current smoking status, number of cigarettes smoked per day, pack-years of smoking, and years since quitting was noted. Complete blood count including platelet indices such as platelet count, MPV, platelet distribution width (PDW), platelet large cell ratio (P-LCR), and plateletcrit (PCT) were determined. On the basis of their smoking characteristics, smokers were grouped as mild, moderate, and heavy.

Result: Compared with nonsmokers, smokers showed significantly high values of MPV, and PDW (P o 0.05). MPV, PDW, and P-LCR were found to be positively associated with intensity of smoking, pack-year, and duration of smoking.

Conclusion: The smokers showed higher MPV, PDW, and P-LCR, which might forecast possible high risk for developing thromboembolic disease in smokers.

Key words: Smokers, Platelet Count, Mean Platelet Volume


 
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REFERENCES
1. WHO. Global Report on Trends in Prevalence of Tobacco Smoking 2015. ISBN 978-92-4-156492-2 (NLM classification: WM 290). Geneva: WHO, 2015.
2. Green CR, Rodgman A. The tobacco chemists' research conference: a half century forum for advances in analytical methodology of tobacco and its products. Recent Adv Tobacco Sci. 1996;22:131–304.
3. Gitte RN. Effect of cigarette smoking on plasma fibrinogen and platelet count. Asian J Med Sci. 2011;2:181–4.
4. Abel GA, Hays JT, Decker PA, Croghan GA, Kuter DJ, Rigotti NA. Effects of biochemically confirmed smoking cessation on white blood cell count. Mayo Clin Proc. 2005;80(8):1022–8. [DOI via Crossref]    [Pubmed]   
5. Yarnell JW, Baker IA, Sweetnam PM, Bainton D, O'Brien JR, Whitehead PJ, et al. Fibrinogen, viscosity and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell collaborative heart disease studies. Circulation. 1991;83:836–44. [DOI via Crossref]    [Pubmed]   
6. de Heens GL, Kikkert R, Aarden LA, van der Velden U, Loos BG. Effects of smoking on the ex vivo cytokine production. J Periodont Res. 2009;44:28–34. [DOI via Crossref]    [Pubmed]   
7. Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L, Whincup PH. Association between cigarette smoking, pipe/cigar smoking, and smoking cessation, haemostatic and inflammatory markers for cardiovascular disease. Eur Heart J. 2005;26(17): 1765–73. [DOI via Crossref]    [Pubmed]   
8. Van Tiel EL, Peeters PH, Smit HA, Nagelderke NJ, Van Loon AJ, Grobbee DE, et al. Quitting smoking may restore hematological characteristics within five years. Ann Epidemiol. 2002;12:378–88. [DOI via Crossref]   
9. Islam MM, Amin MR, Begum S, Akther D, Rahman A. Total count of white blood cells in adult male smokers. J Bangladesh Soc Physiol. 2007;2:49–53.
10. Kume A, Kume T, Masuda K, Shibuya F, Yamzaki H. Dosedependent effect of cigarette smoke on blood biomarkers in healthy volunteers: Observations from smoking and non-smoking. J Health Sci. 2009;55(2):259–64. [DOI via Crossref]   
11. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arvelier D, Rajakanagas A, Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation. 1994;90:583–612. [DOI via Crossref]    [Pubmed]   
12. Ruf A, Patscheke H. Flow cytometric detection of activated platelets: comparison of determining shape change, fibrinogen binding, and P-selectin expression. Semin Thromb Hemost. 1995;21:146–51. [DOI via Crossref]    [Pubmed]   
13. Gurney D, Lip GY, Blann AD. A reliable plasma marker of platelet activation: does it exist? Am J Hematol. 2002;70:139–44. [DOI via Crossref]    [Pubmed]   
14. Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J. 2001;22:1561–71. [DOI via Crossref]    [Pubmed]   
15. Coban E, Yazicioglu G, Berkant Avci A, Akcit F. The mean platelet volume in patients with essential and white coat hypertension. Platelets. 2005;16:435–8. [DOI via Crossref]    [Pubmed]   
16. Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2004;15:475–8. [DOI via Crossref]    [Pubmed]   
17. Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke. 2004;35:1688–91. [DOI via Crossref]    [Pubmed]   
18. Boos CJ, Beevers GD, Lip GY. Assessment of platelet activation indices using the ADVIATM 120 amongst high-risk patients with hypertension. Ann Med. 2007;39(1):72–8. [DOI via Crossref]    [Pubmed]   
19. Pasupathi P, Bakthavathsalam G, Rao Y, Farook J. Cigarette smoking—effect of metabolic health risk: A review. Diabetes Metab Syndr Clin Res Rev. 2009;3:120–7. [DOI via Crossref]   
20. Wolfram R, Chehne F, Oguogho A, Sinzinger H. Narghile (water pipe) smoking influences platelet function and (iso-)eicosanoids. Life Sci. 2003;74:47–53. [DOI via Crossref]    [Pubmed]   
21. Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol. 1992;14(4):281–7. [DOI via Crossref]    [Pubmed]   
22. Butkiewicz AM, Kemona-Chetnik I, Dymicka-Piekarska V, MatowickaKarna J, Kemona H, Radziwon P. Does smoking affect thrombocytopoiesis and platelet activation in women and men? Adv Med Sci. 2006;51:123–6. [Pubmed]   
23. Meenakshisundaram R, Rajendiran C, Thirumalaikolundhusubramanian P. Lipid and lipoprotein profiles among middle aged smokers: a study from southern India. Tob Induc Dis. 2010;8:11–4. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
24. Kaito K, Otsubo H, Usui N, Yoshida M, Tanno J, Kurihara E, et al. Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. Br J Haematol. 2005;128(5):698–702. [DOI via Crossref]    [Pubmed]   
25. European Society of Cardiology (ESC). Passive smoking increases platelet activation in healthy people. ScienceDaily. August 25, 2012.
26. Varol E, Icli A, Kocyigit S, Erdogan D, Ozaydin M, Dogan A. Effect of smoking cessation on mean platelet volume. Clin Appl Thromb Hemost. 2013;19(3):315–9. [DOI via Crossref]    [Pubmed]   
27. Arslan E, Yakar T, Yavas¸oðlu I. The effect of smoking on mean platelet volume and lipid profile in young male subjects. Anadolu Kardiyol Derg. 2008;8(6):422–5. [Pubmed]   
28. Ihara A, Kawamoto T, Matsumoto K, Shouno S, Morimoto T, Noma Y. Relationship between hemostatic factors and the platelet index in patients with ischemic heart disease. Pathophysiol Haemost Thromb. 2006;35(5):388–91. [DOI via Crossref]    [Pubmed]   
29. Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, Inamdar AK. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol. 2006;59(2):146–9. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
30. Sachdev R, Tiwari AK, Goel S, Raina V, Sethi M. Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other. Indian J Pathol Microbiol. 2014;57:231–5. [DOI via Crossref]    [Pubmed]   
31. Gorelick P. Stroke prevention. Arch Neurol. 1995;52:347–55. [DOI via Crossref]    [Pubmed]   
32. Hung J, Lam J, Lacoste L, Letchacovski G. Cigarette smoking acutely increases platelet thrombus formation in patients with coronary artery disease taking aspirin. Circulation. 1995;92:2432–6. [DOI via Crossref]    [Pubmed]   
33. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1): 28–32. [Pubmed]    [PMC Free Fulltext]   

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How to Cite this Article
Pubmed Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo. Evaluation of the impact of cigarette smoking on platelet parameters. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 426-430. doi:10.5455/njppp.2015.5.1009201570


Web Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo. Evaluation of the impact of cigarette smoking on platelet parameters. http://www.njppp.com/?mno=201636 [Access: November 21, 2018]. doi:10.5455/njppp.2015.5.1009201570


AMA (American Medical Association) Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo. Evaluation of the impact of cigarette smoking on platelet parameters. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 426-430. doi:10.5455/njppp.2015.5.1009201570



Vancouver/ICMJE Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo. Evaluation of the impact of cigarette smoking on platelet parameters. Natl J Physiol Pharm Pharmacol. (2015), [cited November 21, 2018]; 5(5): 426-430. doi:10.5455/njppp.2015.5.1009201570



Harvard Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo (2015) Evaluation of the impact of cigarette smoking on platelet parameters. Natl J Physiol Pharm Pharmacol, 5 (5), 426-430. doi:10.5455/njppp.2015.5.1009201570



Turabian Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo. 2015. Evaluation of the impact of cigarette smoking on platelet parameters. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 426-430. doi:10.5455/njppp.2015.5.1009201570



Chicago Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo. "Evaluation of the impact of cigarette smoking on platelet parameters." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 426-430. doi:10.5455/njppp.2015.5.1009201570



MLA (The Modern Language Association) Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo. "Evaluation of the impact of cigarette smoking on platelet parameters." National Journal of Physiology, Pharmacy and Pharmacology 5.5 (2015), 426-430. Print. doi:10.5455/njppp.2015.5.1009201570



APA (American Psychological Association) Style

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo (2015) Evaluation of the impact of cigarette smoking on platelet parameters. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 426-430. doi:10.5455/njppp.2015.5.1009201570





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