E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
31 / 10 / 2020

 


Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study

Arathy R, Santosh Pillai, Sreedevi N S, Rajeev Aravindakshan, Rajmohan G, Sujith J Chandy.


Abstract
Background: Progestogens and selective estrogen receptor modulators are used in treating dysfunctional uterine bleeding (DUB). There is a lack of consensus regarding the best agent.

Aim and Objective: To compare the effectiveness and safety of ormeloxifene and medroxyprogesterone acetate (MPA) in DUB.

Materials and Methods: A comparative evaluation of gynecology outpatients with DUB at a tertiary care teaching hospital by a prospective interventional quasi-random design. Patients having DUB were allocated into two groups based on treatment with ormeloxifene (n = 20) and MPA (n = 20). Each patient was followed up for 3 months and evaluated for: (a) Menstrual blood loss assessed using pictorial blood loss assessment chart (PBAC) score and presence of clots, (b) endometrial thickness, (c) hemoglobin (Hb) level, (d) assessment of symptoms, and (e) adverse effects. Mann–Whitney U test and Chi-square test were used to compare both groups.

Results: There was a significant reduction in PBAC score and passage of clots compared to baseline in both groups. An increase in Hb was statistically significant in MPA group. Decrease in PBAC score, increase in Hb, and decrease in endometrial thickness after treatment was not significant between groups. In ormeloxifene group, symptoms significantly improved after 1 month and 75% patients had amenorrhea.

Conclusion: Ormeloxifene, with less frequent administration and higher tolerability, can be used as an effective alternative to MPA for controlling menstrual blood loss.

Key words: Menstrual Blood Loss; Progestogen; Selective Estrogen Receptor Modulators


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Arathy R
Articles by Santosh Pillai
Articles by Sreedevi N S
Articles by Rajeev Aravindakshan
Articles by Rajmohan G
Articles by Sujith J Chandy
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

R A, Pillai S, S SN, Aravindakshan R, G R, Chandy SJ. Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study. Natl J Physiol Pharm Pharmacol. 2021; 11(3): 246-252. doi:10.5455/njppp.2021.11.10285202024102020


Web Style

R A, Pillai S, S SN, Aravindakshan R, G R, Chandy SJ. Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study. https://www.njppp.com/?mno=17666 [Access: March 14, 2024]. doi:10.5455/njppp.2021.11.10285202024102020


AMA (American Medical Association) Style

R A, Pillai S, S SN, Aravindakshan R, G R, Chandy SJ. Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study. Natl J Physiol Pharm Pharmacol. 2021; 11(3): 246-252. doi:10.5455/njppp.2021.11.10285202024102020



Vancouver/ICMJE Style

R A, Pillai S, S SN, Aravindakshan R, G R, Chandy SJ. Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study. Natl J Physiol Pharm Pharmacol. (2021), [cited March 14, 2024]; 11(3): 246-252. doi:10.5455/njppp.2021.11.10285202024102020



Harvard Style

R, A., Pillai, . S., S, . S. N., Aravindakshan, . R., G, . R. & Chandy, . S. J. (2021) Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study. Natl J Physiol Pharm Pharmacol, 11 (3), 246-252. doi:10.5455/njppp.2021.11.10285202024102020



Turabian Style

R, Arathy, Santosh Pillai, Sreedevi N S, Rajeev Aravindakshan, Rajmohan G, and Sujith J Chandy. 2021. Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study. National Journal of Physiology, Pharmacy and Pharmacology, 11 (3), 246-252. doi:10.5455/njppp.2021.11.10285202024102020



Chicago Style

R, Arathy, Santosh Pillai, Sreedevi N S, Rajeev Aravindakshan, Rajmohan G, and Sujith J Chandy. "Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 246-252. doi:10.5455/njppp.2021.11.10285202024102020



MLA (The Modern Language Association) Style

R, Arathy, Santosh Pillai, Sreedevi N S, Rajeev Aravindakshan, Rajmohan G, and Sujith J Chandy. "Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study." National Journal of Physiology, Pharmacy and Pharmacology 11.3 (2021), 246-252. Print. doi:10.5455/njppp.2021.11.10285202024102020



APA (American Psychological Association) Style

R, A., Pillai, . S., S, . S. N., Aravindakshan, . R., G, . R. & Chandy, . S. J. (2021) Effectiveness and safety of ormeloxifene and medroxyprogesterone acetate in dysfunctional uterine bleeding – A prospective interventional quasi-randomized interval clinical study. National Journal of Physiology, Pharmacy and Pharmacology, 11 (3), 246-252. doi:10.5455/njppp.2021.11.10285202024102020