E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
06 / 04 / 2015

 


A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon.


Abstract
Background: Nearly all smokers show some evidence of lung and systemic cellular and/or humoral inflammation, only a few will experience an amplified response and develop chronic obstructive pulmonary disease (COPD). Several studies have shown systemic inflammation in COPD patients with increased neutrophil, macrophage and T lymphocyte numbers, and high concentrations of inflammatory mediators in peripheral blood (C-reactive protein, interleukin (IL)-6, IL-8, and tumor necrosis factor-α (TNF-α)).

Aims and Objective: To study oxidative stress, antioxidant status, and TNF- levels in patients with COPD.

Materials and Methods: Forty-four COPD patients along with an equal number of age- and sex-matched controls were included in study. The levels of malondialdehyde (MDA; by thiobarbituric acid assay), assay of TNF-α (by TNF-α), and total antioxidant were measured.

Results: Malondialdehyde level was found to be significantly higher in all cases, and it was statistically significant in COPD patients with Global Initiative on Obstructive Lung Disease (GOLD) classification grades 2 and 3. Total antioxidant level was significantly lower in all the patients with COPD and was statistically significant in GOLD grades 2 and 3. Like MDA, TNF level was also significantly higher in all the cases with statistically significant increase in GOLD grades 2 and 3.

Conclusion: To better understand the role of these trace elements and oxidative stress in the pathogenesis and complications of COPD, it is recommended to carry out further clinical studies.

Key words: Chronic Obstructive Pulmonary, Disease (COPD); Oxidative Stress; Malondialdehyde (MDA); Tumor Necrosis Factor-α (TNF-α)


 
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How to Cite this Article
Pubmed Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. 2015; 5(2): 105-107. doi:10.5455/njppp.2015.5.230920141


Web Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. https://www.njppp.com/?mno=166942 [Access: March 14, 2024]. doi:10.5455/njppp.2015.5.230920141


AMA (American Medical Association) Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. 2015; 5(2): 105-107. doi:10.5455/njppp.2015.5.230920141



Vancouver/ICMJE Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. (2015), [cited March 14, 2024]; 5(2): 105-107. doi:10.5455/njppp.2015.5.230920141



Harvard Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon (2015) A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol, 5 (2), 105-107. doi:10.5455/njppp.2015.5.230920141



Turabian Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon. 2015. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. National Journal of Physiology, Pharmacy and Pharmacology, 5 (2), 105-107. doi:10.5455/njppp.2015.5.230920141



Chicago Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon. "A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 105-107. doi:10.5455/njppp.2015.5.230920141



MLA (The Modern Language Association) Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon. "A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease." National Journal of Physiology, Pharmacy and Pharmacology 5.2 (2015), 105-107. Print. doi:10.5455/njppp.2015.5.230920141



APA (American Psychological Association) Style

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon (2015) A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. National Journal of Physiology, Pharmacy and Pharmacology, 5 (2), 105-107. doi:10.5455/njppp.2015.5.230920141