E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam.

Abstract
Background: The incidence of autonomic dysfunction has increased in the setting of type 2 diabetes mellitus and various tools have been developed for assessing it. Classical autonomic function tests are one among them.

Objective: To compare the classical autonomic function tests in type 2 diabetes mellitus patients and healthy volunteers

Materials and methods: The present study was conducted at PSG Institute of Medical Sciences and Research, Coimbatore, Tamilnadu on 30 type 2 diabetic patients (cases) and 30 healthy volunteers (controls). Average age of the diabetic patients was 48.53 ± 5.12 (Mean ± SD) and that of volunteers was 47.10 ±3.59 (Mean ± SD). After obtaining informed, written consent Cardio-respiratory parameters such as resting heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured after 10 minutes of supine rest and autonomic function parameters (AFT) such as heart rate and blood pressure response to handgrip, deep breathing difference test and Valsalvo ratio were recorded in them.

Results: Statistical analysis done by using independent Students 't’ test, showed a statistically significant impairment in heart rate response to handgrip (P<0.001), blood pressure response to handgrip (P<0.001), deep breathing test (P<0.001) and Valsalvo ratio (P<0.001).

Conclusion: Results of the present study showed that compared to healthy volunteers significant impairment was present in type 2 diabetes mellitus patients and it was more pronounced for parasympathetic system than sympathetic system.

Key words: Classical autonomic function tests, type 2 diabetes mellitus, healthy volunteers


 
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How to Cite this Article
Pubmed Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 68-71. doi:10.5455/njppp.2015.5.160820141


Web Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. http://www.njppp.com/?mno=165670 [Access: November 21, 2018]. doi:10.5455/njppp.2015.5.160820141


AMA (American Medical Association) Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 68-71. doi:10.5455/njppp.2015.5.160820141



Vancouver/ICMJE Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol. (2015), [cited November 21, 2018]; 5(1): 68-71. doi:10.5455/njppp.2015.5.160820141



Harvard Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam (2015) Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol, 5 (1), 68-71. doi:10.5455/njppp.2015.5.160820141



Turabian Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam. 2015. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 68-71. doi:10.5455/njppp.2015.5.160820141



Chicago Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam. "Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 68-71. doi:10.5455/njppp.2015.5.160820141



MLA (The Modern Language Association) Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam. "Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study." National Journal of Physiology, Pharmacy and Pharmacology 5.1 (2015), 68-71. Print. doi:10.5455/njppp.2015.5.160820141



APA (American Psychological Association) Style

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam (2015) Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 68-71. doi:10.5455/njppp.2015.5.160820141





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