E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Migraine prophylaxis: Efficacy and safety of lisinopril

Neelamma P, Nalini GK, Suresh RM, Deepak P, Sahana GN, Jayashree VN, Bhavishya Keerthi Anna Valder.

Abstract
Background: Migraine is the most common headache, having at least five attacks that last 472 h, that are unilateral, pulsating, moderate or severe in intensity and aggravated by or cause avoidance of routine physical activity and are also accompanied by nausea/vomiting, photophobia. Treatment of headaches can be either abortive or prophylactic. Here meaning of prophylactic treatment is to reduce the frequency or severity of headaches. Very few studies have been done regarding the safety and efficacy of lisinopril in migraine prophylaxis so we focus on prophylactic therapy for migraine.

Aim and Objective: The aim of the study was (i) to compare the effect of propranolol and lisinopril in migraine as prophylaxis and (ii) to assess the adverse drug reaction of lisinopril.

Materials and Methods: Sixty out patients diagnosed with Migraine in medicine department, HIMS Hassan, and willing to give consent are included for 3 months. Thirty Patients/group, Group1 Lisinopril 5 mg/day od and Group2 Propranolol 20 mg tid given regular treatment. All the patients were provided with a migraine diary and advised to record the number of attacks of migraine. Patients were followed-up at the end of 1st and 3rd months. The change in the migraine frequency and pain intensity was checked (Visual Analog Scale) and also adverse drug reaction.

Results: Migraine episodes and headache severity index were reduced by 84% and 43%, with lisinopril compared with propranolol. Days with migraine were reduced in 11 participants for lisinopril. Eight patients reported an adverse effect like cough during lisinopril therapy.

Conclusion: Lisinopril has better prophylactic therapy in migraine.

Key words: Migraine; Prophylaxis; Lisinopril; Propranolol


 
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How to Cite this Article
Pubmed Style

P N, GK N, RM S, P D, GN S, VN J, Valder BKA. Migraine prophylaxis: Efficacy and safety of lisinopril. Natl J Physiol Pharm Pharmacol. 2021; 11(4): 416-420. doi:10.5455/njppp.2021.11.11337202021122020


Web Style

P N, GK N, RM S, P D, GN S, VN J, Valder BKA. Migraine prophylaxis: Efficacy and safety of lisinopril. http://www.njppp.com/?mno=15941 [Access: April 01, 2021]. doi:10.5455/njppp.2021.11.11337202021122020


AMA (American Medical Association) Style

P N, GK N, RM S, P D, GN S, VN J, Valder BKA. Migraine prophylaxis: Efficacy and safety of lisinopril. Natl J Physiol Pharm Pharmacol. 2021; 11(4): 416-420. doi:10.5455/njppp.2021.11.11337202021122020



Vancouver/ICMJE Style

P N, GK N, RM S, P D, GN S, VN J, Valder BKA. Migraine prophylaxis: Efficacy and safety of lisinopril. Natl J Physiol Pharm Pharmacol. (2021), [cited April 01, 2021]; 11(4): 416-420. doi:10.5455/njppp.2021.11.11337202021122020



Harvard Style

P, N., GK, . N., RM, . S., P, . D., GN, . S., VN, . J. & Valder, . B. K. A. (2021) Migraine prophylaxis: Efficacy and safety of lisinopril. Natl J Physiol Pharm Pharmacol, 11 (4), 416-420. doi:10.5455/njppp.2021.11.11337202021122020



Turabian Style

P, Neelamma, Nalini GK, Suresh RM, Deepak P, Sahana GN, Jayashree VN, and Bhavishya Keerthi Anna Valder. 2021. Migraine prophylaxis: Efficacy and safety of lisinopril. National Journal of Physiology, Pharmacy and Pharmacology, 11 (4), 416-420. doi:10.5455/njppp.2021.11.11337202021122020



Chicago Style

P, Neelamma, Nalini GK, Suresh RM, Deepak P, Sahana GN, Jayashree VN, and Bhavishya Keerthi Anna Valder. "Migraine prophylaxis: Efficacy and safety of lisinopril." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 416-420. doi:10.5455/njppp.2021.11.11337202021122020



MLA (The Modern Language Association) Style

P, Neelamma, Nalini GK, Suresh RM, Deepak P, Sahana GN, Jayashree VN, and Bhavishya Keerthi Anna Valder. "Migraine prophylaxis: Efficacy and safety of lisinopril." National Journal of Physiology, Pharmacy and Pharmacology 11.4 (2021), 416-420. Print. doi:10.5455/njppp.2021.11.11337202021122020



APA (American Psychological Association) Style

P, N., GK, . N., RM, . S., P, . D., GN, . S., VN, . J. & Valder, . B. K. A. (2021) Migraine prophylaxis: Efficacy and safety of lisinopril. National Journal of Physiology, Pharmacy and Pharmacology, 11 (4), 416-420. doi:10.5455/njppp.2021.11.11337202021122020