E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Study of certain mechanisms of anti-edema action of dry extract of medicinal plants

Ziyovuddin Zaynutdinovich Khakimov, Alisher Khudayberdievich Rakhmanov, Shukhrat Ravshan Ogli Mavlanov.

Abstract
Background: An actual problem of pharmacology is the search and development of new medications for treatment inflammatory diseases.

Aims and Objectives: The mechanism of the anti-edema action of dry extract of medicinal plants (DEMPs) was established in experiments using various phlogogens.

Materials and Methods: Experimental models of aseptic arthritis were reproduced by subplantar injection of dextran, histamine, and formalin in a volume of 0.1 ml into the hind paw of rats. The preventive effect of DEMP (50 mg/kg) was studied in comparison with diclofenac sodium (10 mg/ kg) and LIV-52 (100 mg/kg).

Results: It is believed that its mechanism is largely associated not only with the antioxidant property of the medication but also with the stimulation of the production of glucocorticoid hormones in the adrenal gland, as well as regulation of the level of pro- and anti-inflammatory interleukins, cortisol, and suppression of the formation of arachidonic acid.

Conclusions: The multicomponent mechanism of the anti-inflammatory action of DEMPs determines its high antiexudative, antiproliferative, and antialterative properties in inflammation with different etiologies.

Key words: Inflammation; Mechanism; Anti-Inflammatory Drugs; Hormones; Interleukins


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ziyovuddin Zaynutdinovich Khakimov
Articles by Alisher Khudayberdievich Rakhmanov
Articles by Shukhrat Ravshan Ogli Mavlanov
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol. 2021; 11(1): 89-95. doi:10.5455/njppp.2021.11.09240202021112020


Web Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. http://www.njppp.com/?mno=132902 [Access: January 01, 2021]. doi:10.5455/njppp.2021.11.09240202021112020


AMA (American Medical Association) Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol. 2021; 11(1): 89-95. doi:10.5455/njppp.2021.11.09240202021112020



Vancouver/ICMJE Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol. (2021), [cited January 01, 2021]; 11(1): 89-95. doi:10.5455/njppp.2021.11.09240202021112020



Harvard Style

Khakimov, Z. Z., Rakhmanov, . A. K. & Mavlanov, . S. R. O. (2021) Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol, 11 (1), 89-95. doi:10.5455/njppp.2021.11.09240202021112020



Turabian Style

Khakimov, Ziyovuddin Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, and Shukhrat Ravshan O'g'li Mavlanov. 2021. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. National Journal of Physiology, Pharmacy and Pharmacology, 11 (1), 89-95. doi:10.5455/njppp.2021.11.09240202021112020



Chicago Style

Khakimov, Ziyovuddin Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, and Shukhrat Ravshan O'g'li Mavlanov. "Study of certain mechanisms of anti-edema action of dry extract of medicinal plants." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 89-95. doi:10.5455/njppp.2021.11.09240202021112020



MLA (The Modern Language Association) Style

Khakimov, Ziyovuddin Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, and Shukhrat Ravshan O'g'li Mavlanov. "Study of certain mechanisms of anti-edema action of dry extract of medicinal plants." National Journal of Physiology, Pharmacy and Pharmacology 11.1 (2021), 89-95. Print. doi:10.5455/njppp.2021.11.09240202021112020



APA (American Psychological Association) Style

Khakimov, Z. Z., Rakhmanov, . A. K. & Mavlanov, . S. R. O. (2021) Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. National Journal of Physiology, Pharmacy and Pharmacology, 11 (1), 89-95. doi:10.5455/njppp.2021.11.09240202021112020