E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings

Alisher Djumaev, Shokhista Tashmukhamedova.

Abstract
Background: Polyvinyl alcohol (PVA) -based hydrogels are promising biomaterials and suitable candidates for application as wound dressings due to their excellent biocompatibility and favorable properties.

Aims and Objectives: The present research focuses on the studying physical and chemical properties of PVA- chemistry manufacturing and controls (CMC) -based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings.

Materials and Methods: An aqueous solution of carboxymethyl cellulose was mixed in a certain ratio with PVA, to avoid the risks of chemical reagents and cross-linkers, for structure formation, the physical method of freezing-thawing cross-linking was used instead of using traditional chemical cross-linking.

Results: The physical and chemical properties of the obtained hydrogels, such as the gel fraction (GF), water uptake capacity, and protein adsorption, as well as viscoelastic properties, have been studied. The increased content of CMC reduced the GF, elasticity, and strength. However, this led to an increase in the degree of swelling and protein adsorption.

Conclusions: Hydrogels were developed using a physical method for application as wound dressings based on the PVA and CMC containing Inebrin derived from the medicinal plant Lagochílus inebrians as a model of topical hemostatic agent for capillary bleeding.

Key words: Hydrogel; Polyvinyl Alcohol; Sodium Carboxymethyl Cellulose; Inebrin; Freeze-thawing Method


 
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Pubmed Style

Djumaev A, Tashmukhamedova S. Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings. Natl J Physiol Pharm Pharmacol. 2020; 10(10): 905-909. doi:10.5455/njppp.2020.10.08214202020082020


Web Style

Djumaev A, Tashmukhamedova S. Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings. http://www.njppp.com/?mno=121634 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.08214202020082020


AMA (American Medical Association) Style

Djumaev A, Tashmukhamedova S. Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings. Natl J Physiol Pharm Pharmacol. 2020; 10(10): 905-909. doi:10.5455/njppp.2020.10.08214202020082020



Vancouver/ICMJE Style

Djumaev A, Tashmukhamedova S. Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(10): 905-909. doi:10.5455/njppp.2020.10.08214202020082020



Harvard Style

Djumaev, A. & Tashmukhamedova, . S. (2020) Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings. Natl J Physiol Pharm Pharmacol, 10 (10), 905-909. doi:10.5455/njppp.2020.10.08214202020082020



Turabian Style

Djumaev, Alisher, and Shokhista Tashmukhamedova. 2020. Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings. National Journal of Physiology, Pharmacy and Pharmacology, 10 (10), 905-909. doi:10.5455/njppp.2020.10.08214202020082020



Chicago Style

Djumaev, Alisher, and Shokhista Tashmukhamedova. "Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 905-909. doi:10.5455/njppp.2020.10.08214202020082020



MLA (The Modern Language Association) Style

Djumaev, Alisher, and Shokhista Tashmukhamedova. "Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings." National Journal of Physiology, Pharmacy and Pharmacology 10.10 (2020), 905-909. Print. doi:10.5455/njppp.2020.10.08214202020082020



APA (American Psychological Association) Style

Djumaev, A. & Tashmukhamedova, . S. (2020) Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings. National Journal of Physiology, Pharmacy and Pharmacology, 10 (10), 905-909. doi:10.5455/njppp.2020.10.08214202020082020