E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model

Olusoji Adebusoye Oyesola, Philemon H-D Shallie, Ifabunmi Oduyemi Osonuga, Olaniyi Azeez Soetan, Ifedolapo Ibukunoluwa-Gloria Owoeye.

Abstract
Background: Diabetes mellitus is a serious disorder of carbohydrate, protein, and fat metabolism researchers on alternative medications in the management of diabetes with low costly and little or no side effect over long-term use still continue.

Aim and Objective: This study evaluated how Momordica charantia (MC) improved biochemical indices in alloxan-induced diabetic rats.

Materials and Methods: Twenty-five male rats whose weights were between 150 and 200 g used for this study were divided into five groups with five rats per group. Group A received water, Groups B, C, D, and E were all diabetic but received water, aqueous leaf extract of MC, aqueous leaf extract of MC, and anti-diabetic drug and anti-diabetic drug only, respectively. Treatments were carried out for 21 days; from the blood sample, liver enzymes, lipid profile, blood electrolytes, and glucose were determined using standard methods.

Results: Observation from results showed that blood glucose, liver enzymes, lipid profile, and blood electrolytes in diabetic groups treated with MC when compared with diabetic group reduced significantly (P < 0.05).

Conclusion: The management of diabetes induced with alloxan in rats treated with aqueous leaf extract of MC reduced the chance of chronic renal failure, hyperlipidemia, liver
disease, and excessive gain in body weight.

Key words: Diabetes; Management; Momordica charantia; Biochemical Indices


 
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How to Cite this Article
Pubmed Style

Oyesola OA, Shallie PH, Osonuga IO, Soetan OA, Owoeye II. Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model. Natl J Physiol Pharm Pharmacol. 2020; 10(9): 788-794. doi:10.5455/njppp.2020.10.06169202016072020


Web Style

Oyesola OA, Shallie PH, Osonuga IO, Soetan OA, Owoeye II. Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model. http://www.njppp.com/?mno=118529 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.06169202016072020


AMA (American Medical Association) Style

Oyesola OA, Shallie PH, Osonuga IO, Soetan OA, Owoeye II. Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model. Natl J Physiol Pharm Pharmacol. 2020; 10(9): 788-794. doi:10.5455/njppp.2020.10.06169202016072020



Vancouver/ICMJE Style

Oyesola OA, Shallie PH, Osonuga IO, Soetan OA, Owoeye II. Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(9): 788-794. doi:10.5455/njppp.2020.10.06169202016072020



Harvard Style

Oyesola, O. A., Shallie, . P. H., Osonuga, . I. O., Soetan, . O. A. & Owoeye, . I. I. (2020) Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model. Natl J Physiol Pharm Pharmacol, 10 (9), 788-794. doi:10.5455/njppp.2020.10.06169202016072020



Turabian Style

Oyesola, Olusoji Adebusoye, Philemon H-D Shallie, Ifabunmi Oduyemi Osonuga, Olaniyi Azeez Soetan, and Ifedolapo Ibukunoluwa-Gloria Owoeye. 2020. Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model. National Journal of Physiology, Pharmacy and Pharmacology, 10 (9), 788-794. doi:10.5455/njppp.2020.10.06169202016072020



Chicago Style

Oyesola, Olusoji Adebusoye, Philemon H-D Shallie, Ifabunmi Oduyemi Osonuga, Olaniyi Azeez Soetan, and Ifedolapo Ibukunoluwa-Gloria Owoeye. "Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 788-794. doi:10.5455/njppp.2020.10.06169202016072020



MLA (The Modern Language Association) Style

Oyesola, Olusoji Adebusoye, Philemon H-D Shallie, Ifabunmi Oduyemi Osonuga, Olaniyi Azeez Soetan, and Ifedolapo Ibukunoluwa-Gloria Owoeye. "Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model." National Journal of Physiology, Pharmacy and Pharmacology 10.9 (2020), 788-794. Print. doi:10.5455/njppp.2020.10.06169202016072020



APA (American Psychological Association) Style

Oyesola, O. A., Shallie, . P. H., Osonuga, . I. O., Soetan, . O. A. & Owoeye, . I. I. (2020) Momordica charantia improves biochemical indices in alloxan-induced diabetic rat model. National Journal of Physiology, Pharmacy and Pharmacology, 10 (9), 788-794. doi:10.5455/njppp.2020.10.06169202016072020