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Original Research 


Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease

Houndjo DS, Loubano-Voumbi G, Gnahore Eric, Camara Abdou Aziz, Diop Doudou, Sarr Abdou, Diaw Mor, Sow Abdou K, Seck Aissatou, Toure Maimouna, Coly Mame Saloum, BA Awa, Gaye Magaye, Mbengue Arame, BA Abdoulaye, Sar Fatou Bintou, Samb Abdoulaye.

Abstract
Background: Parkinson disease (PD) is a neurodegenerative affection. At the pre-symptomatic stage, the clinical manifestations are mainly cognitive.

Aim and Objective: Our study explores the effects of Voacanga Africana (VOC) on cognitive disorders, more importantly on depressive troubles, in a mouse model (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP) of PD.

Materials and Methods: We used albinos mice (n = 39) taken from the “Institut de Recherche et Développement” based in Dakar. These albinos mice were divided into two groups each composed of three lots. The first group was treated over 15 days (D) with VOC, water (W), and MPTP on D1 (L1: Control [no MPTP/W/VOC]; L2: [MPTP D1 + W D1]; and L3: [MPTP D1 + VOC D1]). The second group was also treated over a period of 30 days. Mice were pretreated with distilled water (W) and VOC 15 days before induction of the disease [L4: Control (no MPTP/W/VOC); L5: (W D1+ MPTP D15); and L6: (VOC D1+ MPTP D15)]. After different protocols of treatment, we used tests to assess motor skills and depression among the selected animals. Tests were carried out weekly and the ANOVAtest and the post-test Bonferroni allowed us to compare the average of the different groups.

Results: MPTP + VOC subjects were less depressed (P < 0.0001; D15) (P < 0.0001; D30) and had better sensorimotor coordination (P < 0.001; D15) than MPTP + W subjects regardless of the period.

Conclusion: These preliminary results could confirm our hypothesis that the VOC has antidepressant effect and potentially a positive effect on motor performance in the pre-symptomatic stage of PD.

Key words: Voacanga Africana; Parkinson Disease; Neurodegenerative


 
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How to Cite this Article
Pubmed Style

DS H, G L, Eric G, Aziz CA, Doudou D, Abdou S, Mor D, K SA, Aissatou S, Maimouna T, Saloum CM, Awa B, Magaye G, Arame M, Abdoulaye B, Bintou SF, Abdoulaye S. Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease. Natl J Physiol Pharm Pharmacol. 2020; 10(9): 782-787. doi:10.5455/njppp.2020.10.06146202016072020


Web Style

DS H, G L, Eric G, Aziz CA, Doudou D, Abdou S, Mor D, K SA, Aissatou S, Maimouna T, Saloum CM, Awa B, Magaye G, Arame M, Abdoulaye B, Bintou SF, Abdoulaye S. Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease. http://www.njppp.com/?mno=112640 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.06146202016072020


AMA (American Medical Association) Style

DS H, G L, Eric G, Aziz CA, Doudou D, Abdou S, Mor D, K SA, Aissatou S, Maimouna T, Saloum CM, Awa B, Magaye G, Arame M, Abdoulaye B, Bintou SF, Abdoulaye S. Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease. Natl J Physiol Pharm Pharmacol. 2020; 10(9): 782-787. doi:10.5455/njppp.2020.10.06146202016072020



Vancouver/ICMJE Style

DS H, G L, Eric G, Aziz CA, Doudou D, Abdou S, Mor D, K SA, Aissatou S, Maimouna T, Saloum CM, Awa B, Magaye G, Arame M, Abdoulaye B, Bintou SF, Abdoulaye S. Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(9): 782-787. doi:10.5455/njppp.2020.10.06146202016072020



Harvard Style

DS, H., G, . L., Eric, . G., Aziz, . C. A., Doudou, . D., Abdou, . S., Mor, . D., K, . S. A., Aissatou, . S., Maimouna, . T., Saloum, . C. M., Awa, . B., Magaye, . G., Arame, . M., Abdoulaye, . B., Bintou, . S. F. & Abdoulaye, . S. (2020) Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease. Natl J Physiol Pharm Pharmacol, 10 (9), 782-787. doi:10.5455/njppp.2020.10.06146202016072020



Turabian Style

DS, Houndjo, Loubano-Voumbi G, Gnahore Eric, Camara Abdou Aziz, Diop Doudou, Sarr Abdou, Diaw Mor, Sow Abdou K, Seck Aissatou, Toure Maimouna, Coly Mame Saloum, BA Awa, Gaye Magaye, Mbengue Arame, BA Abdoulaye, Sar Fatou Bintou, and Samb Abdoulaye. 2020. Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease. National Journal of Physiology, Pharmacy and Pharmacology, 10 (9), 782-787. doi:10.5455/njppp.2020.10.06146202016072020



Chicago Style

DS, Houndjo, Loubano-Voumbi G, Gnahore Eric, Camara Abdou Aziz, Diop Doudou, Sarr Abdou, Diaw Mor, Sow Abdou K, Seck Aissatou, Toure Maimouna, Coly Mame Saloum, BA Awa, Gaye Magaye, Mbengue Arame, BA Abdoulaye, Sar Fatou Bintou, and Samb Abdoulaye. "Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 782-787. doi:10.5455/njppp.2020.10.06146202016072020



MLA (The Modern Language Association) Style

DS, Houndjo, Loubano-Voumbi G, Gnahore Eric, Camara Abdou Aziz, Diop Doudou, Sarr Abdou, Diaw Mor, Sow Abdou K, Seck Aissatou, Toure Maimouna, Coly Mame Saloum, BA Awa, Gaye Magaye, Mbengue Arame, BA Abdoulaye, Sar Fatou Bintou, and Samb Abdoulaye. "Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease." National Journal of Physiology, Pharmacy and Pharmacology 10.9 (2020), 782-787. Print. doi:10.5455/njppp.2020.10.06146202016072020



APA (American Psychological Association) Style

DS, H., G, . L., Eric, . G., Aziz, . C. A., Doudou, . D., Abdou, . S., Mor, . D., K, . S. A., Aissatou, . S., Maimouna, . T., Saloum, . C. M., Awa, . B., Magaye, . G., Arame, . M., Abdoulaye, . B., Bintou, . S. F. & Abdoulaye, . S. (2020) Assessment of Voacanga Africana effect on cognition and motor ability in a mouse model of Parkinson’s disease. National Journal of Physiology, Pharmacy and Pharmacology, 10 (9), 782-787. doi:10.5455/njppp.2020.10.06146202016072020