E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Drug utilization pattern of anti-epileptic drugs in tertiary care hospital

Ravi K Sori, Priya Gandigawad.

Abstract
Background: Epilepsy is a chronic neurological disorder that requires therapy over prolonged period of time to keep patient seizure free. Although patients respond with monotherapy, refractory epileptic patients require polytherapy. Drug utilization studies provide insight to rational drug prescribing.

Aim and Objective: This study was designed to analyze and to study prescription pattern of antiepileptic drugs in patients with epilepsy in tertiary care hospital.

Materials and Methods: The present study was conducted by collecting data from medical record department. Detailed data of patients diagnosed with epilepsy including demographic details, comorbidities, and allergies admitted from January 2015 to December 2017 in study pro forma were collected.

Results: A total of 386 patientís data were analyzed and it was found that male patients were most affected with epilepsy compared to females. Generalized tonic-clonic seizure (GTCS) was the most commonly diagnosed in majority of the patients. Levetiracetam (42.48%) was the most commonly prescribed drug as monotherapy, followed by phenytoin (11.91%), sodium valproate (8.54%), and carbamazepine (5.18%). The most common combination of drugs in polytherapy were levetiracetam and carbamazepine (12.43%), phenytoin with carbamazepine (8.03%), phenytoin with sodium valproate (7.21%), and phenytoin with lamotrigine (3.86%).

Conclusion: The higher incidence of epilepsy is noted in males of all ages. GTCS was the most common type of epilepsy diagnosed and majority of the patients were prescribed with monotherapy. As it is a retrospective study, there were several limitations in the study such as quality of life of patients, compliance to the drugs, adverse reactions to the drugs were not assessed. Hence, further prospective studies with more sample size should be conducted to assess various factors on drug utilization in epilepsy.

Key words: Epilepsy; Antiepileptic Drugs; Prescription Pattern; Seizures


 
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Pubmed Style

Sori RK, Gandigawad P. Drug utilization pattern of anti-epileptic drugs in tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2021; 11(4): 385-388. doi:10.5455/njppp.2021.11.11323202007122020


Web Style

Sori RK, Gandigawad P. Drug utilization pattern of anti-epileptic drugs in tertiary care hospital. http://www.njppp.com/?mno=11072 [Access: April 01, 2021]. doi:10.5455/njppp.2021.11.11323202007122020


AMA (American Medical Association) Style

Sori RK, Gandigawad P. Drug utilization pattern of anti-epileptic drugs in tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2021; 11(4): 385-388. doi:10.5455/njppp.2021.11.11323202007122020



Vancouver/ICMJE Style

Sori RK, Gandigawad P. Drug utilization pattern of anti-epileptic drugs in tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2021), [cited April 01, 2021]; 11(4): 385-388. doi:10.5455/njppp.2021.11.11323202007122020



Harvard Style

Sori, R. K. & Gandigawad, . P. (2021) Drug utilization pattern of anti-epileptic drugs in tertiary care hospital. Natl J Physiol Pharm Pharmacol, 11 (4), 385-388. doi:10.5455/njppp.2021.11.11323202007122020



Turabian Style

Sori, Ravi K, and Priya Gandigawad. 2021. Drug utilization pattern of anti-epileptic drugs in tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 11 (4), 385-388. doi:10.5455/njppp.2021.11.11323202007122020



Chicago Style

Sori, Ravi K, and Priya Gandigawad. "Drug utilization pattern of anti-epileptic drugs in tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 385-388. doi:10.5455/njppp.2021.11.11323202007122020



MLA (The Modern Language Association) Style

Sori, Ravi K, and Priya Gandigawad. "Drug utilization pattern of anti-epileptic drugs in tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 11.4 (2021), 385-388. Print. doi:10.5455/njppp.2021.11.11323202007122020



APA (American Psychological Association) Style

Sori, R. K. & Gandigawad, . P. (2021) Drug utilization pattern of anti-epileptic drugs in tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 11 (4), 385-388. doi:10.5455/njppp.2021.11.11323202007122020