E-ISSN 2231-3206 | ISSN 2320-4672
 

Review Article 


Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?

Suresh K Sharma, Shiv Kumar Mudgal, Venkatesh S Pai, Jitender Chaturvedi, Rakhi Gaur.

Abstract
Novel corona virus disease (COVID-19) pandemic has seriously affected the entire world; moreover, infection and case fatality rate is quite high in countries located in North Hemisphere, where a large proportion of the population is living with Vitamin D (Vit D) deficiency. Vit D is a secosteroid hormone, which plays an important role in calcium and phosphorous homeostasis, and hence bone strength and also has a significant role in the immune health of an individual. It induces the expression of antimicrobial peptides that can decrease viral replication and also reduces the level of pro-inflammatory cytokines while enhancing the level of anti-inflammatory cytokines. Vit D supplementation in daily single doses (3002000 IU/day) for 812 weeks had more protective effect for viral infections than large doses given at fixed intervals (100,000 or 200,000 IU per month or every 3 months). This evidence based review emphasizes the role of Vit D in the immune response to viral infections and proposes the immense value of Vit D supplementation, for the prevention and treatment of COVID-19.

Key words: Coronavirus Disease-19; Cytokine Storm; Immune Response; Influenza; Severe Acute Respiratory Syndrome-Coronavirus-2; Vitamin D


 
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How to Cite this Article
Pubmed Style

Sharma SK, Mudgal SK, Pai VS, Chaturvedi J, Gaur R. Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?. Natl J Physiol Pharm Pharmacol. 2020; 10(7): 511-518. doi:10.5455/njppp.2020.10.05132202024052020


Web Style

Sharma SK, Mudgal SK, Pai VS, Chaturvedi J, Gaur R. Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?. http://www.njppp.com/?mno=109555 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.05132202024052020


AMA (American Medical Association) Style

Sharma SK, Mudgal SK, Pai VS, Chaturvedi J, Gaur R. Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?. Natl J Physiol Pharm Pharmacol. 2020; 10(7): 511-518. doi:10.5455/njppp.2020.10.05132202024052020



Vancouver/ICMJE Style

Sharma SK, Mudgal SK, Pai VS, Chaturvedi J, Gaur R. Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(7): 511-518. doi:10.5455/njppp.2020.10.05132202024052020



Harvard Style

Sharma, S. K., Mudgal, . S. K., Pai, . V. S., Chaturvedi, . J. & Gaur, . R. (2020) Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?. Natl J Physiol Pharm Pharmacol, 10 (7), 511-518. doi:10.5455/njppp.2020.10.05132202024052020



Turabian Style

Sharma, Suresh K, Shiv Kumar Mudgal, Venkatesh S Pai, Jitender Chaturvedi, and Rakhi Gaur. 2020. Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?. National Journal of Physiology, Pharmacy and Pharmacology, 10 (7), 511-518. doi:10.5455/njppp.2020.10.05132202024052020



Chicago Style

Sharma, Suresh K, Shiv Kumar Mudgal, Venkatesh S Pai, Jitender Chaturvedi, and Rakhi Gaur. "Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 511-518. doi:10.5455/njppp.2020.10.05132202024052020



MLA (The Modern Language Association) Style

Sharma, Suresh K, Shiv Kumar Mudgal, Venkatesh S Pai, Jitender Chaturvedi, and Rakhi Gaur. "Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?." National Journal of Physiology, Pharmacy and Pharmacology 10.7 (2020), 511-518. Print. doi:10.5455/njppp.2020.10.05132202024052020



APA (American Psychological Association) Style

Sharma, S. K., Mudgal, . S. K., Pai, . V. S., Chaturvedi, . J. & Gaur, . R. (2020) Vitamin D: A cheap yet effective bullet against coronavirus disease-19 Are we convinced yet?. National Journal of Physiology, Pharmacy and Pharmacology, 10 (7), 511-518. doi:10.5455/njppp.2020.10.05132202024052020