E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A cross-sectional study on cardiac autonomic functions in psoriasis patients

Neha Aggarwal, Jyotsna Shukla, Saroj Purohit, Amit Tak, Bhoopendra Patel.

Abstract
Background: Psoriasis is a chronic, genetically determined and immune-mediated inflammatory disease of unknown etiology with a prevalence of 0.442.8% in India. The literature reports an increased risk of cardiovascular diseases in psoriatic patients. The present study was designed to explore the autonomic nervous system functions in psoriatic patients.

Aim and Objective: The objective of the present study was to assess cardiac autonomic functions in psoriasis patients aged 3040 years as compared to age- and sex-matched healthy controls.

Materials and Methods: The present study was conducted in the Department of Physiology, SMS Medical College, Jaipur. Forty psoriatic patients of both genders were recruited from the Dermatology Department and forty, age- and gender-matched healthy subjects were taken as controls subjects from among employees of SMS Medical College, Jaipur. Prior approval and consent were obtained by the institutional ethics committee and institutional research review board. Parasympathetic function tests include E:I ratio, 30:15 ratio (lying to standing ratio), and Valsalva ratio; sympathetic function tests included blood pressure (BP) response to standing and sustained hand grip.

Results: Change in diastolic BP during isometric hand grip exercise was significantly lower in psoriasis patients (P < 0.05). Change in systolic BP on immediate standing was higher in psoriasis group (P < 0.05). E:I ratio, Valsalva ratio, and 30:15 ratio were also significantly decreased (P < 0.05) in psoriasis patients as compared to the healthy controls.

Conclusion: The deranged autonomic function tests in psoriasis patients suggested definite cardiac autonomic dysfunction. Autonomic dysfunction might put the psoriasis patients at greater cardiovascular disease risk. Therefore, autonomic function assessment of psoriasis patients is necessary for a better prognosis.

Key words: Psoriasis; Sympathetic; Parasympathetic; Cardiovascular


 
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How to Cite this Article
Pubmed Style

Aggarwal N, Shukla J, Purohit S, Tak A, Patel B. A cross-sectional study on cardiac autonomic functions in psoriasis patients. Natl J Physiol Pharm Pharmacol. 2020; 10(9): 722-725. doi:10.5455/njppp.2020.10.05125202019052020


Web Style

Aggarwal N, Shukla J, Purohit S, Tak A, Patel B. A cross-sectional study on cardiac autonomic functions in psoriasis patients. http://www.njppp.com/?mno=107020 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.05125202019052020


AMA (American Medical Association) Style

Aggarwal N, Shukla J, Purohit S, Tak A, Patel B. A cross-sectional study on cardiac autonomic functions in psoriasis patients. Natl J Physiol Pharm Pharmacol. 2020; 10(9): 722-725. doi:10.5455/njppp.2020.10.05125202019052020



Vancouver/ICMJE Style

Aggarwal N, Shukla J, Purohit S, Tak A, Patel B. A cross-sectional study on cardiac autonomic functions in psoriasis patients. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(9): 722-725. doi:10.5455/njppp.2020.10.05125202019052020



Harvard Style

Aggarwal, N., Shukla, . J., Purohit, . S., Tak, . A. & Patel, . B. (2020) A cross-sectional study on cardiac autonomic functions in psoriasis patients. Natl J Physiol Pharm Pharmacol, 10 (9), 722-725. doi:10.5455/njppp.2020.10.05125202019052020



Turabian Style

Aggarwal, Neha, Jyotsna Shukla, Saroj Purohit, Amit Tak, and Bhoopendra Patel. 2020. A cross-sectional study on cardiac autonomic functions in psoriasis patients. National Journal of Physiology, Pharmacy and Pharmacology, 10 (9), 722-725. doi:10.5455/njppp.2020.10.05125202019052020



Chicago Style

Aggarwal, Neha, Jyotsna Shukla, Saroj Purohit, Amit Tak, and Bhoopendra Patel. "A cross-sectional study on cardiac autonomic functions in psoriasis patients." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 722-725. doi:10.5455/njppp.2020.10.05125202019052020



MLA (The Modern Language Association) Style

Aggarwal, Neha, Jyotsna Shukla, Saroj Purohit, Amit Tak, and Bhoopendra Patel. "A cross-sectional study on cardiac autonomic functions in psoriasis patients." National Journal of Physiology, Pharmacy and Pharmacology 10.9 (2020), 722-725. Print. doi:10.5455/njppp.2020.10.05125202019052020



APA (American Psychological Association) Style

Aggarwal, N., Shukla, . J., Purohit, . S., Tak, . A. & Patel, . B. (2020) A cross-sectional study on cardiac autonomic functions in psoriasis patients. National Journal of Physiology, Pharmacy and Pharmacology, 10 (9), 722-725. doi:10.5455/njppp.2020.10.05125202019052020