E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Role of Vitamin D in pre-hypertension and its association with cellular senescence

Himaja Kanumala, Hari Krishna Bandi, Madhusudhana Pulaganti, Venkatachalam Madras.

Abstract
Background: Reports suggest that, in Indian subcontinent, there is 70100% deficiency of Vitamin D (Vit-D), playing pivotal role in higher risk of development of bone diseases and several noncommunicable disease conditions such as malignancies, metabolic diseases, and cardiovascular disease. Reports on role of Vit-D on cellular senescence in pre-hypertension (pre-HTN) were not available.

Aims and Objectives: The aims of the study were to explore the relationship between Vit-D and cellular senescence measured using the enzyme telomerase in pre-HTN.

Materials and Methods: This investigation was carried out in 41 pre-hypertensives and equal number of age- and gender-matched controls. Cellular senescence was measured by increased levels of telomerase and Vit-D was assessed with using commercially available ELISA assay kits.

Results: Weight and BMI, Systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), rate pressure product ( RPP) and telomerase levels were high and vi-D levels were low in pre-HTN group. Low levels of Vit-D were negatively correlated with telomerase, HR, SBP, and PP.

Conclusion: We concluded that the lower Vit-D levels in pre-HTN could lead to derangements in cardiovascular homeostatic mechanism and enhance the speed of cellular senescence measured by telomerase.

Key words: Cellular Senescence; Pre-hypertension; Telomerase; Vitamin D


 
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How to Cite this Article
Pubmed Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol. 2020; 10(6): 499-503. doi:10.5455/njppp.2020.10.04101202028042020


Web Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. http://www.njppp.com/?mno=101573 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.04101202028042020


AMA (American Medical Association) Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol. 2020; 10(6): 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Vancouver/ICMJE Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(6): 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Harvard Style

Kanumala, H., Bandi, . H. K., Pulaganti, . M. & Madras, . V. (2020) Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol, 10 (6), 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Turabian Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. 2020. Role of Vitamin D in pre-hypertension and its association with cellular senescence. National Journal of Physiology, Pharmacy and Pharmacology, 10 (6), 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Chicago Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. "Role of Vitamin D in pre-hypertension and its association with cellular senescence." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 499-503. doi:10.5455/njppp.2020.10.04101202028042020



MLA (The Modern Language Association) Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. "Role of Vitamin D in pre-hypertension and its association with cellular senescence." National Journal of Physiology, Pharmacy and Pharmacology 10.6 (2020), 499-503. Print. doi:10.5455/njppp.2020.10.04101202028042020



APA (American Psychological Association) Style

Kanumala, H., Bandi, . H. K., Pulaganti, . M. & Madras, . V. (2020) Role of Vitamin D in pre-hypertension and its association with cellular senescence. National Journal of Physiology, Pharmacy and Pharmacology, 10 (6), 499-503. doi:10.5455/njppp.2020.10.04101202028042020