E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Role of Vitamin D in pre-hypertension and its association with cellular senescence

Himaja Kanumala, Hari Krishna Bandi, Madhusudhana Pulaganti, Venkatachalam Madras.

Abstract
Background: Reports suggest that, in Indian subcontinent, there is 70–100% deficiency of Vitamin D (Vit-D), playing pivotal role in higher risk of development of bone diseases and several noncommunicable disease conditions such as malignancies, metabolic diseases, and cardiovascular disease. Reports on role of Vit-D on cellular senescence in pre-hypertension (pre-HTN) were not available.

Aims and Objectives: The aims of the study were to explore the relationship between Vit-D and cellular senescence measured using the enzyme telomerase in pre-HTN.

Materials and Methods: This investigation was carried out in 41 pre-hypertensives and equal number of age- and gender-matched controls. Cellular senescence was measured by increased levels of telomerase and Vit-D was assessed with using commercially available ELISA assay kits.

Results: Weight and BMI, Systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), rate pressure product ( RPP) and telomerase levels were high and vi-D levels were low in pre-HTN group. Low levels of Vit-D were negatively correlated with telomerase, HR, SBP, and PP.

Conclusion: We concluded that the lower Vit-D levels in pre-HTN could lead to derangements in cardiovascular homeostatic mechanism and enhance the speed of cellular senescence measured by telomerase.

Key words: Cellular Senescence; Pre-hypertension; Telomerase; Vitamin D


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Himaja Kanumala
Articles by Hari Krishna Bandi
Articles by Madhusudhana Pulaganti
Articles by Venkatachalam Madras
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. doi:10.5455/njppp.2020.10.04101202028042020


Web Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. http://www.njppp.com/?mno=101573 [Access: May 06, 2020]. doi:10.5455/njppp.2020.10.04101202028042020


AMA (American Medical Association) Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. doi:10.5455/njppp.2020.10.04101202028042020



Vancouver/ICMJE Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. doi:10.5455/njppp.2020.10.04101202028042020



Harvard Style

Kanumala, H., Bandi, . H. K., Pulaganti, . M. & Madras, . V. (2020) Role of Vitamin D in pre-hypertension and its association with cellular senescence. doi:10.5455/njppp.2020.10.04101202028042020



Turabian Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. 2020. Role of Vitamin D in pre-hypertension and its association with cellular senescence. doi:10.5455/njppp.2020.10.04101202028042020



Chicago Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. "Role of Vitamin D in pre-hypertension and its association with cellular senescence." doi:10.5455/njppp.2020.10.04101202028042020



MLA (The Modern Language Association) Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. "Role of Vitamin D in pre-hypertension and its association with cellular senescence." doi:10.5455/njppp.2020.10.04101202028042020



APA (American Psychological Association) Style

Kanumala, H., Bandi, . H. K., Pulaganti, . M. & Madras, . V. (2020) Role of Vitamin D in pre-hypertension and its association with cellular senescence. doi:10.5455/njppp.2020.10.04101202028042020





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Most Cited Articles
  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 11 times [Click to see citing articles]

  • Pattern of mobile phone usage and its effects on psychological health, sleep, and academic performance in students of a medical university
    Naveenta Gupta, Sonia Garg, Khushdeep Arora
    Natl J Physiol Pharm Pharmacol. 2016; 6(2): 132-139
    » Abstract & References » doi: 10.5455/njppp.2016.6.0311201599
    Cited : 11 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 11 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 10 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 7 times [Click to see citing articles]